Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
about
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturationRelating the chondrocyte gene network to growth plate morphology: from genes to phenotypeUcma, a novel secreted cartilage-specific protein with implications in osteogenesisGli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiationLimb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossificationHuman GLI3 intragenic conserved non-coding sequences are tissue-specific enhancers.Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb developmentEvidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits.Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen.Gene expression profiling of the hedgehog signaling pathway in human meningiomas.Recent research on the growth plate: Recent insights into the regulation of the growth plateEctodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3.SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions.A transitional extracellular matrix instructs cell behavior during muscle regeneration.Constitutive activation of Gli2 impairs bone formation in postnatal growing miceCilia involvement in patterning and maintenance of the skeletonHedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.Spatial and temporal regulation of gene expression in the mammalian growth plate.Parathyroid hormone-related protein: an update.A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance.Development of the endochondral skeletonRegulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Dominant activation of the hedgehog signaling pathway in the ovary alters theca development and prevents ovulation.Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limbCoordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development.The chondrocytic journey in endochondral bone growth and skeletal dysplasia.The role of hedgehog signalling in skeletal health and disease.Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.Mutational screening of GLI3, SHH, preZRS, and ZRS in 102 Chinese children with nonsyndromic polydactyly.Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture.The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling.Cis-regulatory underpinnings of human GLI3 expression in embryonic craniofacial structures and internal organs.
P2860
Q26995910-CABB4D74-EA38-4D04-98B8-0F9F054FE2F7Q27305048-8292C8D1-D083-49D2-B489-A8FA8E088B32Q28512237-292E95C3-CA35-400F-9901-A7B43043693AQ28587566-58887320-BB37-4225-AA3B-D04BD3A6A59BQ28590845-4A7A524A-501C-48B6-88F5-B879BDF1A526Q28591410-38414ED4-1E63-4E2A-9686-9892E57132A1Q33281754-CE502B02-EBAE-4E05-AE02-1A50102CD974Q33567281-C5205E03-9B06-44C0-AF3E-388124907446Q33901266-940BFCBC-308F-4D01-9754-072F654CAD05Q33937536-3D59A5C7-7BD6-45E8-BF8C-6861630F7BCCQ33959137-756A3107-3134-49D7-9344-94EE865BDED4Q34046963-1AD4243F-9B5F-4A49-910D-5DAC2877CA98Q34064378-74A1B258-58F5-478D-9B86-1277BCB3A9AFQ34071414-16A0AC3D-47B8-4B92-A45A-211A84FC2E33Q34138974-765122EC-FA38-4AC9-BA81-6E1ABECC774BQ34149015-0F6826E9-36D6-49E6-AC68-247DD50C6B7BQ34576113-27B82E0E-204F-4E98-8A7B-83E421EE0301Q35022641-FA0A6D48-BB00-48DE-B111-AFDF04EC58E5Q35485124-2818BC80-DDC9-4DD3-92E5-5988A3BED2D0Q36162905-48B5C7CA-4FB0-4226-A4EC-35829AE30641Q36201545-40963C6B-CBC0-4A33-987C-01C634F1568CQ36380533-1CB3F3DB-344A-4152-A3E5-86DE7CA1DE5AQ36629738-C2685CA4-57D5-45D4-B1A3-6A6C940A0BFDQ36832578-C3139C46-F5BF-4515-A2FA-9CB3E47C939FQ36921151-D4693C83-71E3-461F-A005-7A9A3AB54357Q37044705-B5A504DE-30C3-4B65-A3F2-398C0DCD7142Q37176290-C5D4FF3E-C457-4B11-B06A-0236E156B31BQ37199110-63D42A9B-1F61-41D4-9E1A-036FA096FAEFQ37314413-861C042C-8988-4CA3-BA57-E25172C55CBEQ37770435-83D863E2-B8F5-45D6-B859-811BF54E746CQ38200066-B8AD324A-9B6B-41D9-8C79-0F4D6E319C1CQ38528618-DA200474-0814-4695-8F3C-3BF32AE21B7CQ38688231-CE9F54E7-5122-453D-95BE-8A1B26C21E79Q39162665-731E7AE3-766D-4F6C-B290-785BFB726B4EQ40362439-57A889D3-747F-487F-8427-0D2F9B4F28FAQ40474217-189765DA-46EE-4D69-893C-37D5506F71FEQ42036556-D667A123-BCF1-449D-9D54-7D30C87A5E03Q42658620-C9EF0A5C-8997-4395-BD58-AD7D40519F28Q42799207-5B4FF101-F64A-42F9-8D6E-1F46EBF79641Q46600830-BF31607C-8D23-49FB-84DC-239498689D7E
P2860
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
description
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Dezember 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/12/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/12/01)
@nl
наукова стаття, опублікована в грудні 2005
@uk
مقالة علمية (نشرت في ديسمبر 2005)
@ar
name
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@ast
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@en
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@nl
type
label
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@ast
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@en
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@nl
prefLabel
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@ast
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@en
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@nl
P2093
P356
P1433
P1476
Gli3 acts as a repressor downs ...... of chondrocyte differentiation
@en
P2093
Andrea Vortkamp
Lydia Koziel
Manuela Wuelling
Sabine Schneider
P304
P356
10.1242/DEV.02097
P407
P577
2005-12-01T00:00:00Z