ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
about
Melanoma: from melanocyte to genetic alterations and clinical optionsCross-species models of human melanomaRal GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformationChimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness, and DNA repair deficiencyDysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytesModeling metastasis biology and therapy in real time in the mouse lung.Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.The inflammatory network: bridging senescent stroma and epithelial tumorigenesis.Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications.Dynamics of ARF regulation that control senescence and cancer.Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish."Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.Regulation of senescence in cancer and aging.ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation.Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2.E2F1-dependent oncogenic addiction of melanoma cells to MDM2.Frequent p16-independent inactivation of p14ARF in human melanoma.Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing.Hair follicle bulge cultures yield class III β-tubulin-positive melanoglial cellsImplications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology.Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.Absence of germline CDKN2A mutation in Sicilian patients with familial malignant melanoma: Could it be a population-specific genetic signature?Cutaneous melanoma in genetically modified animals.A role for Mediator complex subunit MED13L in Rb/E2F-induced growth arrestPower of PTEN/AKT: Molecular switch between tumor suppressors and oncogenesLoss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC.Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activitiesMelanomagenesis: overcoming the barrier of melanocyte senescence.Malignant melanoma in the 21st century: the emerging molecular landscape.The role of p53 in pigmentation, tanning and melanoma.GAB2 induces tumor angiogenesis in NRAS-driven melanoma.Lentivirus-mediated bifunctional cell labeling for in vivo melanoma studyCutaneous melanoma: how does ultraviolet light contribute to melanocyte transformation?Genetics and epigenetics of melanoma.Met amplification and tumor progression in Cdkn2a-deficient melanocytes.Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.Pathways of oncogene-induced senescence in human melanocytic cells
P2860
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P2860
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2007
@ast
im Juni 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/06/26)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/06/26)
@nl
наукова стаття, опублікована в червні 2007
@uk
name
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@ast
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@en
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@nl
type
label
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@ast
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@en
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@nl
prefLabel
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@ast
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@en
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@nl
P2093
P2860
P3181
P356
P1476
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
@en
P2093
Elena V. Sviderskaya
Glenn Merlino
Miriam Anver
Norman E. Sharpless
Paul Krimpenfort
Ronald A. Depinho
Scott Lowe
Takeshi Ichikawa
P2860
P304
10968–10973
P3181
P356
10.1073/PNAS.0611638104
P407
P577
2007-06-26T00:00:00Z