Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayPartial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisDNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formationArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseFunctional and biochemical dissection of the structure-specific nuclease ARTEMISShelterin complex and associated factors at human telomeresFunctional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joiningDNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombinationThe metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombinationModeling the study of DNA damage responses in miceAutophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.Phosphorylation of Artemis following irradiation-induced DNA damage.Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis.The response to and repair of RAG-mediated DNA double-strand breaksNon-homologous end-joining, a sticky affairRole of non-homologous end joining in V(D)J recombinationThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlRad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stabilityDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsThe GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse HematopoiesisIn vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathwayHistone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cellsHomozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeArtemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentRegulation of the DNA Damage Response to DSBs by Post-Translational Modifications.The multifunctional SNM1 gene family: not just nucleasesRadiosensitive severe combined immunodeficiency disease.Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.Mechanisms of double-strand break repair in somatic mammalian cells.Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism.HCoDES reveals chromosomal DNA end structures with single-nucleotide resolutionNovel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiencyChoosing the right path: does DNA-PK help make the decision?Artemis: guarding small children and, now, the genomeComplete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer
P2860
Q22065419-FCAC0E49-1243-4BA1-87B4-69C7CB62B206Q24554368-56CB711D-7EC8-4958-943C-CA2C77C624EBQ24559729-29553F8A-3163-4638-9AA0-21FC5D4A8621Q24561444-B64CCBAF-71F7-4330-B48C-1649C5E4D086Q24564574-4D72389D-B0F6-4D18-AB0A-654D8C130AE1Q24601577-D5F5AC11-216B-4DA9-9BDE-A64DE63A2DDAQ24624166-C505D739-0A45-41CB-BE5C-6E0E6F240265Q24644085-C9FA2D2C-E982-4387-87AA-4847D6365FA4Q24646190-9C1EDC62-6F7A-4639-A82A-9877AE592140Q24647735-43B83D08-897B-4D62-89B7-B90C6D2E8625Q26826949-D86DAE9B-F142-4E6E-995C-5DBFE1B2B601Q27919641-ED8DF336-C050-4871-A71E-40B81E5BF070Q27919664-AE98EA20-ADD2-4345-BA6F-83D93C76E351Q27919672-5AC083A2-5875-43C5-99A1-E6B380A80D1BQ27919681-A67B6D1C-9CF1-4724-97C5-44EF0CCBC01BQ28256889-C39855D8-2BDE-48D8-BDD5-3E29DC6D03C3Q28260337-0E3BDC55-9553-42FB-8C2E-05BD45DC7D0CQ28266265-65D8AC0E-516F-4669-A60D-58DCA8C57958Q28296356-854124D7-C544-4911-8CD9-416F170FD5AEQ28506612-C46A30F0-196E-4687-8BED-7FF5C4DBE5B7Q28513655-9CDE9200-D831-4BF6-9861-D9617B97902DQ28592466-D096AB1F-56EC-489D-A2A5-B3CDBD045052Q33273630-B361BD48-3554-4770-8768-7C527BF130ADQ33589397-A38E70E8-A669-4FDA-85A4-F229035889F5Q33591110-97854142-6DEB-4136-AB6B-663B0CAEA285Q33729755-FAB55B36-1427-4B98-8772-0A1A5FCC6140Q33733794-A9A04E4A-397B-44C4-B652-FFD7939BD304Q33850170-800CA751-FDD5-47F4-9B7E-BEBD3A4D9245Q33886979-CBB4455A-769A-486A-BF65-657F5B6BFCF5Q33995521-F685D3F4-BD32-4A49-9976-1D251619FD67Q34095701-69ECBFB6-A8F3-4852-9A83-46398039BF23Q34124251-587E98E3-F532-443E-B879-C5D9C4E12D16Q34317108-C3F10C21-4960-4BFA-99C5-2399CC7098DFQ34568846-463C8DD9-D3AF-497F-A546-6932F9547D73Q34622114-694972DE-1974-4904-A363-CAB869B3E451Q34747083-6DFCC65E-9C82-478E-891F-FA0A7FA2C5F7Q34999354-74CF707F-9180-4B5C-9E49-18772570B8F6Q35029335-B8577ABC-CFC9-4BE4-A964-79420F4A24EEQ35060355-0CCDF346-8BD7-4B55-AEE9-C4CA4701988BQ35133845-9CFC0411-1D96-4B06-807A-65C95D5576FF
P2860
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@ast
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@en
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@nl
type
label
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@ast
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@en
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@nl
prefLabel
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@ast
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@en
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@nl
P2093
P3181
P1433
P1476
Leaky Scid phenotype associate ...... sing in Artemis-deficient mice
@en
P2093
Chengming Zhu
Frederick W. Alt
Hwei Ling Cheng
Jayanta Chaudhuri
Jeff DeVido
John Manis
Scott Whitlow
Sean Rooney
P304
P3181
P356
10.1016/S1097-2765(02)00755-4
P577
2002-12-01T00:00:00Z