Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
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Function, regulation and pathological roles of the Gab/DOS docking proteinsMolecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinaseThe major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingInteraction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2Principles of interleukin (IL)-6-type cytokine signalling and its regulationPositive and negative regulation of T-cell activation through kinases and phosphatasesPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic functionA direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinaseStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsEnhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkEssential role of Gab1 for signaling by the c-Met receptor in vivoGAB2--a scaffolding protein in cancerStructure and function of Gab2 and its role in cancer (Review)Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domainsOncogenic Signaling Adaptor ProteinsGab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisCytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulationEngagement of Gab1 and Gab2 in erythropoietin signalingInhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partnersDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cellsSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingSHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motilityCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesEpidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytesGab3, a new DOS/Gab family member, facilitates macrophage differentiation.Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activationNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayA novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingA novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
P2860
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P2860
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
description
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
scientific journal article
@en
vedecký článok (publikovaný 1998/12/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/12/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в грудні 1998
@uk
مقالة علمية (نشرت في ديسمبر 1998)
@ar
name
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@ast
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@en
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@nl
type
label
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@ast
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@en
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@nl
prefLabel
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@ast
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@en
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@nl
P2093
P1433
P1476
Cloning of p97/Gab2, the major ...... tokine-induced gene activation
@en
P2093
B. G. Neel
J. C. Pratt
S. J. Burakoff
P304
P356
10.1016/S1097-2765(00)80288-9
P577
1998-12-01T00:00:00Z