Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
about
A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanismA phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosisβ-1,3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cellsTargeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1.Shaping cups into phagosomes and macropinosomesAn intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles.vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus.Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infectionAn effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.Phospholipase D2 is required for efficient endocytic recycling of transferrin receptorsDeficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).The Role of Phospholipase D in Regulated Exocytosis.Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.Phospholipase D signaling: orchestration by PIP2 and small GTPases.Cytokine secretion requires phosphatidylcholine synthesisPhospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.Lipid signaling and the modulation of surface charge during phagocytosis.Molecular mechanisms of PLD function in membrane traffic.Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking.Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Phosphoinositides and engulfmentThe life cycle of phagosomes: formation, maturation, and resolution.Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages.Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29.Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.InlB-mediated Listeria monocytogenes internalization requires a balanced phospholipase D activity maintained through phospho-cofilin.The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response.Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis.Hydrolysis of PC to PA by PLDThe localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages.Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.
P2860
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P2860
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/08/15)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/15)
@nl
наукова стаття, опублікована в серпні 2004
@uk
مقالة علمية (نشرت في 15-8-2004)
@ar
name
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@ast
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@en
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@nl
type
label
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@ast
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@en
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@nl
prefLabel
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@ast
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@en
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@nl
P2093
P1476
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
@en
P2093
David J. Kusner
James A. Barton
Shankar S. Iyer
Sylvain Bourgoin
P304
P356
10.4049/JIMMUNOL.173.4.2615
P407
P577
2004-08-15T00:00:00Z