Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.
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A palmitoylation switch mechanism regulates Rac1 function and membrane organization.Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitroThe Rac1 hypervariable region in targeting and signaling: a tail of many storiesRandom versus directionally persistent cell migrationRac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysisIntestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.Association of lipid metabolism with ovarian cancerProtein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading.Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membranePhospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerHeterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensorDeficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxisADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity.Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Phospholipase D: enzymology, functionality, and chemical modulationDisruption of the phospholipase D gene attenuates the virulence of Aspergillus fumigatusEDI3 links choline metabolism to integrin expression, cell adhesion and spreadingDifferential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activityA new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cellsA GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migrationAberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells.Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis.Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities.Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling.Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils.Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.
P2860
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P2860
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Phospholipase D activity regul ...... cation to the plasma membrane.
@ast
Phospholipase D activity regul ...... cation to the plasma membrane.
@en
type
label
Phospholipase D activity regul ...... cation to the plasma membrane.
@ast
Phospholipase D activity regul ...... cation to the plasma membrane.
@en
prefLabel
Phospholipase D activity regul ...... cation to the plasma membrane.
@ast
Phospholipase D activity regul ...... cation to the plasma membrane.
@en
P2093
P2860
P356
P1476
Phospholipase D activity regul ...... cation to the plasma membrane.
@en
P2093
Hye Young Lee
Hyun Wook Kim
Kyung Lock Kim
Pann-Ghill Suh
Sung Ho Ryu
Tobias Meyer
Won Do Heo
Young Chan Chae
P2860
P304
P356
10.1091/MBC.E07-04-0337
P577
2008-05-14T00:00:00Z