Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. - Wikidata - wikimedia - TriplyDB

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

http://www.wikidata.org/entity/Q36739944

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A palmitoylation switch mechanism regulates Rac1 function and membrane organization.Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro The Rac1 hypervariable region in targeting and signaling: a tail of many stories Random versus directionally persistent cell migration Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.Association of lipid metabolism with ovarian cancer Protein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading.Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity.Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Phospholipase D: enzymology, functionality, and chemical modulation Disruption of the phospholipase D gene attenuates the virulence of Aspergillus fumigatus EDI3 links choline metabolism to integrin expression, cell adhesion and spreading Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells.Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis.Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities.Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling.Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils.Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.

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P2860

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

http://www.wikidata.org/entity/Q36739944

description

2008 nî lūn-bûn

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2008年の論文

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Hyun Wook Kim

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Kyung Lock Kim

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Pann-Ghill Suh

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Sung Ho Ryu

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Tobias Meyer

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Won Do Heo

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Young Chan Chae

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P2860

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI

Cell migration: integrating signals from front to back

Cell migration: a physically integrated molecular process

Rho GTPases in cell biology

Phospholipase D1 in caveolae: regulation by protein kinase Calpha and caveolin-1

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1

Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function

Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex

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