The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
about
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeIdentification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophagesPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayEnhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptorJoint disease caused by defective gp130-mediated STAT signaling.Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorCytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulationDifferential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathwaysSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalingThe COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signalingProtein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cellsInsulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cellsActivation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expressionNegative regulation of the JAK/STAT pathway.How to extinguish lymphocyte activation, immunotyrosine-based inhibition motif (ITIM)-bearing molecules a solution?Signaling through Gp130: toward a general scenario of cytokine action.Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells.Proinflammatory stem cell signaling in cardiac ischemiaA cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b.Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.Sp3 is involved in the regulation of SOCS3 gene expression.Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.Identification of a novel gp130-responsive site in the vasoactive intestinal peptide cytokine response element.Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.Regulation of SOCS-1 expression by translational repression.Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1.PTPN11 binds p-Y759-IL6STProtein tyrosine phosphatases: their role in insulin action and potential as drug targets.
P2860
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P2860
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
description
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im September 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/09/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/09/01)
@nl
наукова стаття, опублікована у вересні 1997
@uk
مقالة علمية (نشرت في سبتمبر 1997)
@ar
name
The protein tyrosine phosphata ...... r induction of gene expression
@ast
The protein tyrosine phosphata ...... r induction of gene expression
@en
The protein tyrosine phosphata ...... r induction of gene expression
@nl
type
label
The protein tyrosine phosphata ...... r induction of gene expression
@ast
The protein tyrosine phosphata ...... r induction of gene expression
@en
The protein tyrosine phosphata ...... r induction of gene expression
@nl
prefLabel
The protein tyrosine phosphata ...... r induction of gene expression
@ast
The protein tyrosine phosphata ...... r induction of gene expression
@en
The protein tyrosine phosphata ...... r induction of gene expression
@nl
P2093
P1433
P1476
The protein tyrosine phosphata ...... r induction of gene expression
@en
P2093
G Yancopoulos
S A Reeves
T Farruggella
T Servidei
P304
P356
10.1016/S0960-9822(06)00298-3
P407
P577
1997-09-01T00:00:00Z