A role for Src in signal relay by the platelet-derived growth factor alpha receptor
about
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progressionPI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinasesA reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αGene expression of human lung cancer cell line CL1-5 in response to a direct current electric fieldPhosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos inductionSignaling via Shc family adapter proteinsSrc family kinases are required for integrin but not PDGFR signal transduction.Pulmonary thrombotic microangiopathy caused by gastric carcinomaGrowth factors outside the PDGF family drive experimental PVR.Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.Metazoan-like signaling in a unicellular receptor tyrosine kinase.An evolutionary and structural perspective on T cell antigen receptor function.Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis.SRC family kinases and receptors: analysis of three activation mechanisms by dynamic systems modelingFluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis.Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells.Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor.Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis.N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy.Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.Spatial signaling networks converge at the adaptor protein Shc.The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart.Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity.Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK.Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL.Alphavbeta6-Fyn signaling promotes oral cancer progression.Hepatic stellate cell-derived PDGFRα-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.SH2 domain of Src binds to the active receptor
P2860
Q22253382-C5A6500A-BA05-4EF4-9DAC-336643E12862Q24322037-B5F679A2-0F2A-4979-9C87-33F930467DFBQ24339412-7A8898A9-5810-4690-A743-70DE3585F773Q27317026-52642007-6F17-4933-8227-6030D575DF9FQ28145948-DDDCFCC0-FBDD-41B3-AF46-AB9AAEA8F132Q28199357-41DA202A-AB89-4F94-A753-4AAED767D8D3Q30014832-B96ABEF8-FB85-41F0-BE3F-F71EF6A89AE6Q33388995-E0C6D5D8-4505-4C59-9798-CF225EA82908Q33557530-A0113429-9893-4221-B9B5-3FBC8C0B4D0BQ33852190-D7FF9267-FBFF-49EA-808B-E4CEDDEAC803Q34465364-F87AA166-4BF7-45BE-9D04-DA9DC424BCBAQ34582288-6DBC00F8-733C-4861-B28B-A188DDDE5475Q35076666-5DC065C5-B4FE-44C1-9759-074DA786AE09Q36164555-9DD32AAB-A10E-4D77-8D20-235E52F0721FQ36233571-EB69EEFC-D7FE-4FC6-892D-736DCD759F3DQ36481526-4C06538A-CE4B-489C-A540-A6A6B42ED6B6Q36520705-4283E39F-12CD-403C-A526-CB2DEC05AF6FQ39284759-8E36A7E9-B4DA-418A-A4A3-B7A0AF1FA483Q39631039-147A4C21-0A90-4DC6-9335-A698D4631957Q39898210-35E71DD2-6CE9-43F3-87CB-B3091D843FE3Q40037121-E55FB5BC-CC3E-4216-8D84-FD280974C52DQ40710486-86290785-C6CB-482B-B1BE-B25DE16DF305Q40727565-7E639FAC-4193-4014-A583-0A5AEF9DC96AQ40927232-4F0C86BF-42D6-4D65-A5E2-BCE9EFCFCD24Q41526638-8F72FDF4-FA80-4104-8900-504CBCF29B6FQ41838681-A77AEBE8-4F06-4861-9191-11A60ECD099EQ42411756-DECEB80D-2274-4FFA-B153-CA49E476C71CQ42586449-9783FF50-A7F5-4083-8F75-8692A6418C14Q42801916-5662E19A-B0FE-48E9-BAF5-6162DD084EF8Q42815138-EF6D6E80-8605-4848-96A8-2D0E7601F639Q42995228-5D999D18-EF7B-4910-B658-55CBB5589D40Q44454323-937D125C-DDBB-4486-81A8-684A2BFE7C70Q45869400-A9A0EE46-1A4E-4201-BFBA-A9D6498CD6D7Q45948340-990BE015-CE4A-4157-8735-1843F457886CQ48185795-40F221E2-4944-4534-A6C8-B78C6563760DQ50297845-D94E458E-5EF9-45D1-BBBA-B0AC4DC3E794
P2860
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
description
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im März 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/03/06)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/03/06)
@nl
наукова стаття, опублікована в березні 1998
@uk
name
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@ast
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@en
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@nl
type
label
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@ast
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@en
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@nl
prefLabel
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@ast
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@en
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@nl
P2093
P2860
P356
P1476
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
@en
P2093
A. Kazlauskas
C. Bazenet
J. A. Gelderloos
S. Rosenkranz
P2860
P304
P356
10.1074/JBC.273.10.5908
P407
P577
1998-03-06T00:00:00Z