Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene
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Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaPhosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cellsThe SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatmentErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinasesStimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channelsA role for Src in signal relay by the platelet-derived growth factor alpha receptorEffects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Identification and characterization of a novel cytoskeleton-associated pp60src substrate.Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11.Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancersIdentification of the in vitro phosphorylation sites on Gs alpha mediated by pp60c-src.Transformation of Rat-1 fibroblasts with the v-src oncogene induces inositol 1,4,5-trisphosphate 3-kinase expressionEpidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling.Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells.Tumor promotion by depleting cells of protein kinase C delta.Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.Cellular functions regulated by phosphorylation of EGFR on Tyr845.Transformation of chicken embryo fibroblasts by v-src uncouples beta1 integrin-mediated outside-in but not inside-out signalingTyrosine phosphorylation regulates maturation of receptor tyrosine kinases.Participation of p97Eps8 in Src-mediated transformation.Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein.The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor.Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotypeAtypical receptor-mediated signal transduction events in the EGF-dependent growth-inhibited cell line, MDA-468.pp60src-mediated phosphorylation of connexin 43, a gap junction protein.Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events.Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation.
P2860
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P2860
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Phosphorylation and activation ...... ransformed by the src oncogene
@ast
Phosphorylation and activation ...... ransformed by the src oncogene
@en
type
label
Phosphorylation and activation ...... ransformed by the src oncogene
@ast
Phosphorylation and activation ...... ransformed by the src oncogene
@en
prefLabel
Phosphorylation and activation ...... ransformed by the src oncogene
@ast
Phosphorylation and activation ...... ransformed by the src oncogene
@en
P2093
P2860
P356
P1476
Phosphorylation and activation ...... ransformed by the src oncogene
@en
P2093
D L Fitzgerald
W J Wasilenko
P2860
P304
P356
10.1128/MCB.11.1.309
P407
P577
1991-01-01T00:00:00Z