Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
about
PI3K: An Attractive Candidate for the Central Integration of Metabolism and ReproductionRapamycin and its analogues (rapalogs) for tuberous sclerosis complexTBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-35-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophreniaStructural analysis and functional implications of the negative mTORC1 regulator REDD1Muscle atrophy in transgenic mice expressing a human TSC1 transgeneIdentification and characterization of the interaction between tuberin and 14-3-3zetaInsulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubesRegulation of TSC2 by 14-3-3 bindingPRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexPar-4 inhibits Akt and suppresses Ras-induced lung tumorigenesisDifferential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signalingActivity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningIdentification of a proline-rich Akt substrate as a 14-3-3 binding partnerDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Signaling by target of rapamycin proteins in cell growth controlRegulation of mTOR and cell growth in response to energy stress by REDD1.Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingHypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cellsRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexAmino acids as regulators of gene expressionBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityTumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseThe TOR pathway comes of ageTrypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategyThe effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high-androgen responder and low-androgen responder muscle groupsMammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthSpatial regulation of the mTORC1 system in amino acids sensing pathwayOligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticityPushing the envelope in the mTOR pathway: the second generation of inhibitorsPHLiPPing the switch on Akt and protein kinase C signalingThe tuberous sclerosis complexNext-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategymTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and diseasePhosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKBRapamycin and mTOR kinase inhibitorsCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
P2860
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P2860
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
description
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Juli 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/07/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/07/01)
@nl
наукова стаття, опублікована в липні 2002
@uk
مقالة علمية (نشرت في يوليو 2002)
@ar
name
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@ast
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@en
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@nl
type
label
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@ast
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@en
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@nl
prefLabel
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@ast
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@en
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@nl
P2093
P3181
P1433
P1476
Identification of the tuberous ...... inositide 3-kinase/akt pathway
@en
P2093
Brendan D Manning
John Blenis
Lewis C Cantley
M Nicole Logsdon
P304
P3181
P356
10.1016/S1097-2765(02)00568-3
P577
2002-07-01T00:00:00Z