Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
about
Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancersCullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsCAK-independent activation of CDK6 by a viral cyclinNovel Molecular Markers for Breast CancerThe structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent rolesCDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytesActivation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytesRetinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexesThe N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent mannerA novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10pA U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight formsCdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progressionA role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation.Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity.Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination.Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cellsAltered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation.Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes.Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins.Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7.Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4.Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsNuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence.A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2.The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis.Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation.In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.The RRASK motif in Xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex.Association of Rb with Cyclin E:Cdk2 complexesCyclin E:Cdk2-mediated phosphorylation of Rb
P2860
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P2860
Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
description
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1998
@ast
im März 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/03/03)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/03/03)
@nl
наукова стаття, опублікована в березні 1998
@uk
name
Identification of a substrate- ...... of the retinoblastoma protein
@ast
Identification of a substrate- ...... of the retinoblastoma protein
@en
Identification of a substrate- ...... of the retinoblastoma protein
@nl
type
label
Identification of a substrate- ...... of the retinoblastoma protein
@ast
Identification of a substrate- ...... of the retinoblastoma protein
@en
Identification of a substrate- ...... of the retinoblastoma protein
@nl
prefLabel
Identification of a substrate- ...... of the retinoblastoma protein
@ast
Identification of a substrate- ...... of the retinoblastoma protein
@en
Identification of a substrate- ...... of the retinoblastoma protein
@nl
P2093
P2860
P356
P1476
Identification of a substrate- ...... of the retinoblastoma protein
@en
P2093
B. L. Kelly
J. M. Roberts
K. G. Wolfe
P2860
P304
P356
10.1073/PNAS.95.5.2535
P407
P577
1998-03-03T00:00:00Z