Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

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http://www.wikidata.org/entity/Q34698674

Q34698674

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A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95 HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization.Inhibitory RNA molecules in immunotherapy for cancer.Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell.Regulation of CDK4 Transforming growth factor-beta signaling in normal and malignant hematopoiesis.Immunotherapeutic strategies employing RNA interference technology for the control of cancers.Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Molecular pathogenesis of nodular goiter.Effects of the Smad4 C324Y mutation on thyroid cell proliferation.TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1.Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.Stimulation of cAMP signalling allows isolation of clonal pancreatic precursor cells from adult mouse pancreas.EGF and TGF-β1 Effects on Thyroid Function.Biochemical differences between SUDHL-1 and KARPAS 299 cells derived from t(2;5)-positive anaplastic large cell lymphoma are responsible for the different sensitivity to the antiproliferative effect of p27(Kip1).Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4.Ethanol induces apoptotic death of beta-endorphin neurons in the rat hypothalamus by a TGF-beta 1-dependent mechanism.Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors

P2860

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P2860

Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

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http://www.wikidata.org/entity/Q34698674

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