Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
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Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotypeTyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformationGab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activationThe inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.Tumor vascular changes mediated by inhibition of oncogenic signaling.Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer.Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutationAccelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancerImproved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarityThe Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Dominant negative Ras enhances lactogenic hormone-induced differentiation by blocking activation of the Raf-Mek-Erk signal transduction pathway.Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.Cell type of origin as well as genetic alterations contribute to breast cancer phenotypesPrognosis of treatment response (pathological complete response) in breast cancer.Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis.Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4Signaling Pathway of GP88 (Progranulin) in Breast Cancer Cells: Upregulation and Phosphorylation of c-myc by GP88/Progranulin in Her2-Overexpressing Breast Cancer CellsIn vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.Hyperexpression of mitogen-activated protein kinase in human breast cancer.Drosophila as a tool for personalized medicine: a primerRadiation-induced signaling pathways that promote cancer cell survival (review).Differential regulation of MAP kinase cascade in human colorectal tumorigenesisTyrosine kinase-dependent modulation of 3-hydroxy-3-methylglutaryl-CoA reductase in human breast adenocarcinoma SKBR-3 cellsRAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
P2860
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P2860
Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
description
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im Dezember 1994 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1994/12/01)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/12/01)
@nl
наукова стаття, опублікована в грудні 1994
@uk
مقالة علمية (نشرت في ديسمبر 1994)
@ar
name
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@ast
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@en
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@nl
type
label
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@ast
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@en
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@nl
prefLabel
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@ast
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@en
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@nl
P2093
P1433
P1476
Activation of the Ras signalli ...... er cells overexpressing erbB-2
@en
P2093
P304
P407
P577
1994-12-01T00:00:00Z