about
Biophysical and computational methods to analyze amino acid interaction networks in proteinsProtein stability: computation, sequence statistics, and new experimental methodsFrom systems to structure: bridging networks and mechanismPrinciples of allosteric interactions in cell signalingFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewTwo polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteinsStructural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and RibonucleotidesDesigning Allosteric Control into Enzymes by Chemical Rescue of StructureModulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription FactorsImportance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling AnalysisProtein structural ensembles are revealed by redefining X-ray electron density noiseATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesA novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methodsExploitation of latent allostery enables the evolution of new modes of MAP kinase regulationTowards the computational design of protein post-translational regulationCharacterization of Protein-Protein Interfaces through a Protein Contact Network ApproachProtein sectors: statistical coupling analysis versus conservationEvolution-Based Functional Decomposition of ProteinsPredicting functionally informative mutations in Escherichia coli BamA using evolutionary covariance analysis.Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Covariation Is a Poor Measure of Molecular Coevolution.Evolution of sparsity and modularity in a model of protein allostery.Tertiary model of a plant cellulose synthase.Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein.Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily.Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Large-scale de novo DNA synthesis: technologies and applications.Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species ConservationProfiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switchHot spots in a network of functional sites.Measuring the activity of protein variants on a large scale using deep mutational scanning.Chemical biology strategies for posttranslational control of protein function.SORTCERY-A High-Throughput Method to Affinity Rank Peptide Ligands.Comparative laboratory evolution of ordered and disordered enzymes.Conservation weighting functions enable covariance analyses to detect functionally important amino acids.Coevolved Mutations Reveal Distinct Architectures for Two Core Proteins in the Bacterial Flagellar MotorComputational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Hot spots for allosteric regulation on protein surfaces
@ast
Hot spots for allosteric regulation on protein surfaces
@en
Hot spots for allosteric regulation on protein surfaces
@nl
type
label
Hot spots for allosteric regulation on protein surfaces
@ast
Hot spots for allosteric regulation on protein surfaces
@en
Hot spots for allosteric regulation on protein surfaces
@nl
prefLabel
Hot spots for allosteric regulation on protein surfaces
@ast
Hot spots for allosteric regulation on protein surfaces
@en
Hot spots for allosteric regulation on protein surfaces
@nl
P2093
P2860
P3181
P1433
P1476
Hot spots for allosteric regulation on protein surfaces
@en
P2093
Kimberly A Reynolds
Rama Ranganathan
Richard N McLaughlin
P2860
P304
P3181
P356
10.1016/J.CELL.2011.10.049
P407
P577
2011-12-23T00:00:00Z