Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus - Wikidata - wikimedia - TriplyDB

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

http://www.wikidata.org/entity/Q29615029

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MDA-5 recognition of a murine norovirus DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential ATP-sensitive potassium channels mediate survival during infection in mammals and insects Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions Immune signaling by RIG-I-like receptors ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2 Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.Peroxisomes are signaling platforms for antiviral innate immunity SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2 The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA Activation of MDA5 requires higher-order RNA structures generated during virus infection The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling Mapping a dynamic innate immunity protein interaction network regulating type I interferon production Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway Many stimuli pull the necrotic trigger, an overview Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction Function and regulation of retinoic acid-inducible gene-I A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I MDA-5 is cleaved in poliovirus-infected cells Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation Macrophage Expression of Inflammatory Genes in Response to EMCV Infection Interferon induction by RNA viruses and antagonism by viral pathogens dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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Proceedings of the National Academy of Sciences of the United States of America

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Essential role of mda-5 in typ ...... ephalomyocarditis picornavirus

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Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling.

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Innate immune recognition

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