A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
about
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccinationAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon responsecPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatisStructure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune systemSTING is a direct innate immune sensor of cyclic di-GMPCytosolic Innate Immune Sensing and Signaling upon InfectionVaccine adjuvants as potential cancer immunotherapeuticsDifferential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infectionsCyclic di-GMP: the first 25 years of a universal bacterial second messengerDNA vaccines: a simple DNA sensing matter?Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsSpecies-specific detection of the antiviral small-molecule compound CMA by STINGStructural mechanism of cytosolic DNA sensing by cGASCrystal structures of STING protein reveal basis for recognition of cyclic di-GMPInnate immune detection of microbial nucleic acids.Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of CancerInternational Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseInterferons and viruses: an evolutionary arms race of molecular interactionsType I interferon: friend or foe?The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseAge-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infectionIdentification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophilaAntibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarizationStimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infectionSecreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.Small protein-mediated quorum sensing in a Gram-negative bacterium.The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infectionsMycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potentialListeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGCyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages
P2860
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P2860
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A host type I interferon respo ...... second messenger cyclic-di-GMP
@ast
A host type I interferon respo ...... second messenger cyclic-di-GMP
@en
A host type I interferon respo ...... second messenger cyclic-di-GMP
@nl
type
label
A host type I interferon respo ...... second messenger cyclic-di-GMP
@ast
A host type I interferon respo ...... second messenger cyclic-di-GMP
@en
A host type I interferon respo ...... second messenger cyclic-di-GMP
@nl
prefLabel
A host type I interferon respo ...... second messenger cyclic-di-GMP
@ast
A host type I interferon respo ...... second messenger cyclic-di-GMP
@en
A host type I interferon respo ...... second messenger cyclic-di-GMP
@nl
P2093
P2860
P50
P3181
P356
P1476
A host type I interferon respo ...... second messenger cyclic-di-GMP
@en
P2093
Katherine A Fitzgerald
Kathryn M Monroe
Mary F Fontana
Nathalie T Joncker
Roman Barbalat
Russell E Vance
Sarah M McWhirter
Yoshihiro Hayakawa
P2860
P304
P3181
P356
10.1084/JEM.20082874
P407
P577
2009-08-31T00:00:00Z