Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Vitamin A and Alzheimer's diseasePresenilin 2 interacts with sorcin, a modulator of the ryanodine receptorPresenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateMolecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bThe α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsFamilial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor proteinMetalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingMammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and NotchSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionThe structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptorThe novel presenilin-1-associated protein is a proapoptotic mitochondrial proteinAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationThe transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2bAn alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitorTransmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationNicalin and its binding partner Nomo are novel Nodal signaling antagonistsThe gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sampleHuman aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor proteinReversal of long-term dendritic spine alterations in Alzheimer disease modelsProteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZFWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseNSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoThe rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfersThe presenilinsMolecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and PhosphorylationThe amyloid hypothesis of Alzheimer's disease at 25 yearsTrafficking regulation of proteins in Alzheimer's diseaseDiverse molecular targets for therapeutic strategies in Alzheimer's diseaseγ-Secretase inhibitors and modulators.Cellular mechanisms of γ-secretase substrate selection, processing and toxicityMitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention
P2860
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P2860
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Two transmembrane aspartates i ...... s and gamma-secretase activity
@ast
Two transmembrane aspartates i ...... s and gamma-secretase activity
@en
type
label
Two transmembrane aspartates i ...... s and gamma-secretase activity
@ast
Two transmembrane aspartates i ...... s and gamma-secretase activity
@en
prefLabel
Two transmembrane aspartates i ...... s and gamma-secretase activity
@ast
Two transmembrane aspartates i ...... s and gamma-secretase activity
@en
P2093
P3181
P356
P1433
P1476
Two transmembrane aspartates i ...... s and gamma-secretase activity
@en
P2093
P2888
P3181
P356
10.1038/19077
P407
P577
1999-04-08T00:00:00Z
P6179
1004359799