Rational design of inhibitors that bind to inactive kinase conformations
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Structure prediction and validation of the ERK8 kinase domainDivergent allosteric control of the IRE1α endoribonuclease using kinase inhibitorsA conserved protonation-dependent switch controls drug binding in the Abl kinaseDelineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint ApproachCurrent targeted therapies in the treatment of advanced colorectal cancer: a reviewSomatic DNA mutation analysis in targeted therapy of solid tumoursCharting a Path to Success in Virtual ScreeningJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksKinases as druggable targets in trypanosomatid protozoan parasitesTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsTen things you should know about protein kinases: IUPHAR Review 14Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteinsDiscoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discoveryRational approaches to improving selectivity in drug designExploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Developing irreversible inhibitors of the protein kinase cysteinomePreclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR DysregulationStructural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemiaStructure and regulation of the human Nek2 centrosomal kinaseA systematic interaction map of validated kinase inhibitors with Ser/Thr kinasesTargeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinasesAnchored plasticity opens doors for selective inhibitor design in nitric oxide synthaseSmall Molecule Recognition of c-Src via the Imatinib-Binding ConformationInsights into the Conformational Variability and Regulation of Human Nek2 KinaseStructural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor DesignCrystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug designDiscovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR , Kit, and Src kinases: novel type II inhibitor of gatekeeper mutantsStructural and mechanistic basis for a new mode of glycosyltransferase inhibitionCyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor DesignGenetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORStructural Basis for Selective Small Molecule Kinase Inhibition of Activated c-MetDiscovery of a Potential Allosteric Ligand Binding Site in CDK2A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases: DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTORConformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for CatalysisInsights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma KinaseX-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinaseAffinity-Based Probes Based on Type II Kinase Inhibitors
P2860
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P2860
Rational design of inhibitors that bind to inactive kinase conformations
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Rational design of inhibitors that bind to inactive kinase conformations
@ast
Rational design of inhibitors that bind to inactive kinase conformations
@en
type
label
Rational design of inhibitors that bind to inactive kinase conformations
@ast
Rational design of inhibitors that bind to inactive kinase conformations
@en
prefLabel
Rational design of inhibitors that bind to inactive kinase conformations
@ast
Rational design of inhibitors that bind to inactive kinase conformations
@en
P3181
P356
P1476
Rational design of inhibitors that bind to inactive kinase conformations
@en
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO799
P407
P577
2006-07-01T00:00:00Z
P5875
P6179
1050699600