Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
about
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activityDifferential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factorsIOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activityThe forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanismHistone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alphaMyeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxiaRegulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive elementMolecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alphaSuppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alphaMechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor proteinRegulation of human metabolism by hypoxia-inducible factorRegulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alphaAutophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironmentCardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutationThe VHL tumor suppressor: master regulator of HIFThe human side of hypoxia-inducible factorHIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxiaRegulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayVanadate-induced expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen speciesInfluence of hypoxia and neoangiogenesis on the growth of pancreatic cancerHypoxia and oxidative stress in breast cancer. Hypoxia signalling pathwaysOxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiologyThe polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxiaAscorbate depletion: a critical step in nickel carcinogenesis?Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancersDUBs, New Members in the Hypoxia Signaling clUbTargeting Protein-Protein Interactions in the HIF SystemTargeting hypoxic response for cancer therapyExploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish modelsObstructive sleep apnea and cognitive impairment: addressing the blood-brain barrierHypoxia and metabolic properties of hematopoietic stem cellsHypoxia and Integrin-Mediated Epithelial Restitution during Mucosal InflammationRole of the sympathetic autonomic nervous system in hypoxic remodeling of the fetal cerebral vasculatureRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationMetabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effectThe evolving role of the aryl hydrocarbon receptor (AHR) in the normophysiology of hematopoiesisMGA2 is involved in the low-oxygen response element-dependent hypoxic induction of genes in Saccharomyces cerevisiae.
P2860
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P2860
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@ast
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@en
type
label
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@ast
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@en
prefLabel
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@ast
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@en
P3181
P356
P1476
Hypoxia-inducible factor 1alph ...... pends on redox-induced changes
@en
P2093
P304
P3181
P356
10.1074/JBC.272.36.22642
P407
P577
1997-09-05T00:00:00Z