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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

http://www.wikidata.org/entity/Q29618944

about

Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell Polycomb group genes: keeping stem cell activity in balance Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3 UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression Screening and identification of proteins interacting with nucleostemin MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase Mammary stem cells, self-renewal pathways, and carcinogenesis Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG Cancerous stem cells can arise from pediatric brain tumors Bmi1, stem cells, and senescence regulation MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins Mammary epithelial cell transformation: insights from cell culture and mouse models.Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma Epigenetic Regulation of Hematopoietic Stem Cells Lung cancer stem cells-characteristics, phenotype Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function The functional role of microRNA in acute lymphoblastic leukemia: relevance for diagnosis, differential diagnosis, prognosis, and therapy Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

http://www.wikidata.org/entity/Q29618944

description

2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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type

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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prefLabel

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

@en

P2093

Lessard J

http://www.w3.org/2001/XMLSchema#string

Sauvageau G

http://www.w3.org/2001/XMLSchema#string

P2860

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Differential gene expression profiling of adult murine hematopoietic stem cells.

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255-60

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scholarly article

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263680

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10.1038/NATURE01572

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6937

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423

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2003-05-15T00:00:00Z

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10787428

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1045711316

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12714970

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