A novel multiple-stage antimalarial agent that inhibits protein synthesis
about
Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the wayRecent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetasesExpanding the antimalarial toolkit: Targeting host-parasite interactionsNext-generation antimicrobials: from chemical biology to first-in-class drugsA long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaA triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malariaDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsUDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genesThe mRNA-bound proteome of the human malaria parasite Plasmodium falciparumThe PfAlba1 RNA-binding protein is an important regulator of translational timing in Plasmodium falciparum blood stagesRecent advances in malaria genomics and epigenomicsAlternatives to currently used antimalarial drugs: in search of a magic bulletBiochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active CompoundsEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaComparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitorThe Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic ScreensSelective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparumEpigenetic assays for chemical biology and drug discovery.Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screenA tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.Developing transmission-blocking strategies for malaria control.Discovery of Dual-Stage Malaria Inhibitors with New Targets.A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes.Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Ex Vivo Maturation Assay for Testing Antimalarial Sensitivity of Rodent Malaria Parasites.Pausing on Polyribosomes: Make Way for Elongation in Translational ControlHigh-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Current therapies and future possibilities for drug development against liver-stage malaria.In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agentsAn inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.SC83288 is a clinical development candidate for the treatment of severe malaria.Transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against Sarcoptes scabiei var. cuniculi.Antiplasmodial drug targets: a patent review (2000 - 2013).
P2860
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P2860
A novel multiple-stage antimalarial agent that inhibits protein synthesis
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@ast
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@en
type
label
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@ast
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@en
prefLabel
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@ast
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@en
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
A novel multiple-stage antimalarial agent that inhibits protein synthesis
@en
P2093
Achim Porzelle
Andrew M Blagborough
Andrew Woodland
Brice Campo
Didier Leroy
Francisco Javier Gamo
Frederick Simeons
Grennady Wirjanata
Irene Hallyburton
Iñigo Angulo-Barturen
P2860
P2888
P304
P3181
P356
10.1038/NATURE14451
P407
P50
P577
2015-06-01T00:00:00Z