β-Barrel topology of Alzheimer's β-amyloid ion channels.
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The toxicity of amyloid β oligomersAmyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresOut-of-register -sheets suggest a pathway to toxic amyloid aggregatesAtomic View of a Toxic Amyloid Small OligomerFamilial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers.Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFMAmyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels.Effect of metals on kinetic pathways of amyloid-β aggregationActivity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) poresDisordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.Alzheimer's disease: which type of amyloid-preventing drug agents to employ?Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability.Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicityAntimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation.Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.Antimicrobial properties of amyloid peptides.Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formationPhosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.The higher level of complexity of K-Ras4B activation at the membrane.Mechanism of membrane permeation induced by synthetic β-hairpin peptides.Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.Computational approaches to understanding protein aggregation in neurodegeneration.Cystatin-related epididymal spermatogenic aggregates in the epididymis.Aggregation of amyloids in a cellular context: modelling and experiment.Molecular understanding of a potential functional link between antimicrobial and amyloid peptides.Geometrical principles of homomeric β-barrels and β-helices: Application to modeling amyloid protofilaments.Dewetting transition assisted clearance of (NFGAILS) amyloid fibrils from cell membranes by graphene.Recent Progress in Alzheimer's Disease Research, Part 1: Pathology.Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels.Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model.Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics.Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.
P2860
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P2860
β-Barrel topology of Alzheimer's β-amyloid ion channels.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@ast
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@en
type
label
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@ast
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@en
prefLabel
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@ast
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@en
P50
P1476
β-Barrel topology of Alzheimer's β-amyloid ion channels.
@en
P2093
Hyunbum Jang
Ratnesh Lal
P304
P356
10.1016/J.JMB.2010.10.025
P407
P577
2010-10-21T00:00:00Z