SH2-dependent autophosphorylation within the Tec family kinase Itk.
about
Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavIdentification of an allosteric signaling network within Tec family kinases.Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.Substrate recognition of PLCγ1 via a specific docking surface on Itk.Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler.
P2860
Q27667961-356655BE-1578-459D-8D78-1F9F2606BB7BQ34172793-5B065476-D27D-482F-90FE-15A9B1792C3FQ34873052-B18D0A8B-C769-49C5-AA95-6B523D79608CQ36225697-7CB4770B-1EEF-436C-9441-4ABF791D6576Q37430991-764F4892-EFCA-49A2-BC68-EF547D3F1E97Q37452660-8805CCD7-63B5-45C4-92D7-40E5F2BDA81AQ39970262-672AAC6B-CCAC-4B4B-83FC-C4CF4B87CC87Q40707431-A600201C-CF40-4EAA-9518-802E9FE53CB6
P2860
SH2-dependent autophosphorylation within the Tec family kinase Itk.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@ast
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@en
type
label
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@ast
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@en
prefLabel
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@ast
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@en
P2093
P2860
P1476
SH2-dependent autophosphorylation within the Tec family kinase Itk.
@en
P2093
Amy H Andreotti
Andrew Severin
D Bruce Fulton
Raji E Joseph
P2860
P304
P356
10.1016/J.JMB.2009.06.023
P407
P577
2009-06-11T00:00:00Z