Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
about
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cellsSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsThe B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathwaysCbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cellsB cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling moduleA conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cellsThe biology behind PI3K inhibition in chronic lymphocytic leukaemiaBLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteinsThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersSH2-dependent autophosphorylation within the Tec family kinase Itk.Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membraneThe LMP2A ITAM is essential for providing B cells with development and survival signals in vivoSLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease courseThe fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.Protein kinases: emerging therapeutic targets in chronic lymphocytic leukemia.BLNK mediates Syk-dependent Btk activation.Adapters in lymphocyte signalingThe B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cellsRegulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and SykB-cell antigen-receptor signalling in lymphocyte development.The B-cell receptor signaling pathway as a therapeutic target in CLL.Stability and peptide binding specificity of Btk SH2 domain: molecular basis for X-linked agammaglobulinemiaBruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activationA B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigenPhospholipids: "greasing the wheels" of humoral immunityIdentification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human plateletsCalcium signalling and cell-fate choice in B cells.Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challengeSyk and pTyr'd: Signaling through the B cell antigen receptorConformational snapshots of Tec kinases during signaling.Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Identification of a pre-BCR lacking surrogate light chainDelayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma.
P2860
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P2860
Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@ast
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@en
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@nl
type
label
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@ast
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@en
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@nl
prefLabel
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@ast
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@en
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@nl
P2093
P1433
P1476
Identification of the SH2 doma ...... ptor-coupled calcium signaling
@en
P2093
A Iwamatsu
M Matsushita
S Hashimoto
T Kishimoto
T Kurosaki
T Yamadori
P304
P407
P577
1999-10-01T00:00:00Z