On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
about
Structural basis for the recognition of c-Src by its inactivator CskLinker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domainsMany local motions cooperate to produce the adenylate kinase conformational transitionA conserved protonation-dependent switch controls drug binding in the Abl kinaseAllosteric communication occurs via networks of tertiary and quaternary motions in proteinsA Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal TransductionStructural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentLocking the active conformation of c-Src kinase through the phosphorylation of the activation loopTwo-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capAn electrostatic network and long-range regulation of Src kinasesLigand-induced global transitions in the catalytic domain of protein kinase A.ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.Multidomain assembled states of Hck tyrosine kinase in solution.Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC)Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels.Flexibility and charge asymmetry in the activation loop of Src tyrosine kinasesSending signals dynamically.Biomolecularmodeling and simulation: a field coming of age.The feasibility of parameterizing four-state equilibria using relaxation dispersion measurementsMolecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex.Landscape of kinetically trapped binary assemblies.Single-sweep methods for free energy calculations.Atomic view of the energy landscape in the allosteric regulation of Abl kinase.
P2860
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P2860
On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@ast
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@en
type
label
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@ast
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@en
prefLabel
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@ast
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@en
P2860
P356
P1476
On the importance of a funnele ...... tidomain Src tyrosine kinases.
@en
P2093
Benoît Roux
José D Faraldo-Gómez
P2860
P304
13643-13648
P356
10.1073/PNAS.0704041104
P407
P577
2007-08-15T00:00:00Z