SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
about
Identification of STAT5A and STAT5B target genes in human T cellsRegulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor proteinSubstrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrateAn essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55RThe ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular SwitchDeficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cellsRIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationHematopoietic adaptors in T-cell signaling: potential applications to transplantationADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugationThe N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptorsLRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cellsTyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation.Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAPCTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.T-cell receptor signaling to integrins.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Impairment of immunological synapse formation in adaptively tolerant T cellsADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Membranes as messengers in T cell adhesion signaling.Positive and negative adaptors in T-cell signalling.Gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical significanceRegulation of T-cell receptor signalling by membrane microdomains.Intracellular signalling controlling integrin activation in lymphocytes.AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.Compartmentalization of ITAM and integrin signaling by adapter molecules.Tec kinases, actin, and cell adhesion.Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.Enhancement of LFA-1-mediated T cell adhesion by human T lymphotropic virus type 1 p12I1.Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling moduleSKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodesFunctional anatomy of T cell activation and synapse formation.
P2860
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P248
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P2860
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@ast
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@en
type
label
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@ast
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@en
prefLabel
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@ast
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@en
P2093
P921
P356
P1433
P1476
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
@en
P2093
Abdallah Azouz
Andrew Smith
Christopher E Rudd
Eun-Yi Moon
Helga Schneider
Hongyan Wang
Nancy Hogg
P2888
P304
P356
10.1038/NI913
P407
P577
2003-03-24T00:00:00Z
P6179
1040480447