Structural determinants for the biological activity of Vav proteins.
about
Crucial structural role for the PH and C1 domains of the Vav1 exchange factorRasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responsesVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerVav family exchange factors: an integrated regulatory and functional viewThe Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loopsStructural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1Mutation of Vav1 adaptor region reveals a new oncogenic activation.The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligandMembrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patientsLigand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancerGlobal conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assemblyVav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activityVav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activationVav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseMolecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activationThe N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIAAnalysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screeningCompartmentalization of ITAM and integrin signaling by adapter molecules.From T-cell activation signals to signaling control of anti-cancer immunity.Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomasThe distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia.Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.
P2860
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P2860
Structural determinants for the biological activity of Vav proteins.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural determinants for the biological activity of Vav proteins.
@ast
Structural determinants for the biological activity of Vav proteins.
@en
type
label
Structural determinants for the biological activity of Vav proteins.
@ast
Structural determinants for the biological activity of Vav proteins.
@en
prefLabel
Structural determinants for the biological activity of Vav proteins.
@ast
Structural determinants for the biological activity of Vav proteins.
@en
P2093
P2860
P50
P356
P1476
Structural determinants for the biological activity of Vav proteins
@en
P2093
José L Zugaza
Miguel A López-Lago
Nieves Movilla
P2860
P304
45377-45392
P356
10.1074/JBC.M208039200
P407
P577
2002-09-12T00:00:00Z