Structural determinants of metal-induced conformational changes in HIV-1 integrase.
about
HIV-1 integrase crosslinked oligomers are active in vitroHuman immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes.Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysisComputational approaches for de novo design and redesign of metal-binding sites on proteinsAn inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase.Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases.Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody.Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteinsChanges in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.Solution conformation and dynamics of the HIV-1 integrase core domain.A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediateRaltegravir: molecular basis of its mechanism of actionArchitecture and assembly of HIV integrase multimers in the absence of DNA substratesInhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.Bacterial topoisomerase I as a target for discovery of antibacterial compounds.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.Can the propensity of protein crystallization be increased by using systematic screening with metals?Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1.The positive and negative regulation of Tn10 transposition by IHF is mediated by structurally asymmetric transposon arms.Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.Mechanisms of copper incorporation into human ceruloplasmin.A high-throughput assay for Tn5 Tnp-induced DNA cleavage.Interactions of the human T-cell leukemia virus type-II integrase with the conserved CA in the retroviral long terminal repeat end.Effect of metal binding on the structural stability of pigeon liver malic enzyme.
P2860
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P2860
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@ast
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@en
type
label
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@ast
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@en
prefLabel
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@ast
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@en
P2093
P2860
P356
P1476
Structural determinants of metal-induced conformational changes in HIV-1 integrase.
@en
P2093
Asante-Appiah E
Seeholzer SH
P2860
P304
35078-35087
P356
10.1074/JBC.273.52.35078
P407
P577
1998-12-01T00:00:00Z