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Activation of the JNK pathway is essential for transformation by the Met oncogene

Activation of the JNK pathway is essential for transformation by the Met oncogene

http://www.wikidata.org/entity/Q30176542

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The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis A selective small-molecule inhibitor of c-Jun N-terminal kinase 1 The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps An overview of the c-MET signaling pathway JNK signalling in cancer: in need of new, smarter therapeutic targets Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation Met receptor tyrosine kinase: enhanced signaling through adapter proteins Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes Distinct expression patterns and transforming properties of multiple isoforms of Ost, an exchange factor for RhoA and Cdc42.Transcriptional gene expression profiles of HGF/SF-met signaling pathway in colorectal carcinoma.Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.Hepatocyte growth factor, a versatile signal for developing neurons.Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation.Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment?The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells.Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.ROS, stress-activated kinases and stress signaling in cancer.Sequential activation of ERK and repression of JNK by scatter factor/hepatocyte growth factor in madin-darby canine kidney epithelial cells The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle.c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase.Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes.SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis.The mutationally activated Met receptor mediates motility and metastasis.JNK Signaling in the Control of the Tumor-Initiating Capacity Associated with Cancer Stem Cells.PKC controls HGF-dependent c-Met traffic, signalling and cell migration.Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells.Targeting MUC1 and JNK by RNA interference and inhibitor inhibit the development of hepatocellular carcinoma.Progress in cancer therapy targeting c-Met signaling pathway.

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P2860

Activation of the JNK pathway is essential for transformation by the Met oncogene

http://www.wikidata.org/entity/Q30176542

description

1997 nî lūn-bûn

@nan

1997 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի մայիսին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Activation of the JNK pathway is essential for transformation by the Met oncogene

@ast

Activation of the JNK pathway is essential for transformation by the Met oncogene

@en

type

label

Activation of the JNK pathway is essential for transformation by the Met oncogene

@ast

Activation of the JNK pathway is essential for transformation by the Met oncogene

@en

prefLabel

Activation of the JNK pathway is essential for transformation by the Met oncogene

@ast

Activation of the JNK pathway is essential for transformation by the Met oncogene

@en

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The EMBO Journal

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Activation of the JNK pathway is essential for transformation by the Met oncogene

@en

P2093

Park M

http://www.w3.org/2001/XMLSchema#string

Rodrigues GA

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Schlessinger J

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P2860

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein

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2634-2645

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10

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1169874

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