Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein
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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinaseAn overview of the c-MET signaling pathwayTargeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signalingBiology of MET: a double life between normal tissue repair and tumor progressionViable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar developmentCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesMet receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodiaInvolvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growthCrk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Activation of the JNK pathway is essential for transformation by the Met oncogeneSpecificity and affinity motifs for Grb2 SH2-ligand interactionsHost-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transductionThe tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review.A point mutation in the MET oncogene abrogates metastasis without affecting transformation.Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contactsTumor induction by a transformation-defective polyoma virus mutant blocked in signaling through ShcConstitutive activation of the RON gene promotes invasive growth but not transformation.The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesisGrowth factors and oncogenes as targets in melanoma: lost in translation?c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications.The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms?cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance.Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer TherapyNon-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptorNon-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture.Profiles of cell-to-cell interaction of Mycobacterium intracellulare-induced immunosuppressive macrophages with target T cells in terms of suppressor signal transmission.Insights into the Shc Family of Adaptor Proteins.Activated HGF-c-Met Axis in Head and Neck Cancer.The Role of PI3K in Met Driven Cancer: A Recap
P2860
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P2860
Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@ast
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@en
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@nl
type
label
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@ast
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@en
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@nl
prefLabel
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@ast
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@en
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@nl
P2093
P3181
P356
P1476
Pathways downstream of Shc and ...... ion by the tpr-Met oncoprotein
@en
P2093
D M Kamikura
E D Fixman
M A Naujokas
T M Fournier
P304
P3181
P356
10.1074/JBC.271.22.13116
P407
P577
1996-05-31T00:00:00Z