Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.
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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolutionStructural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking DomainsAutomated genome mining for natural products.Clustering of protein domains for functional and evolutionary studiesIdentification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.Structural enzymology of polyketide synthases.Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender unitsIdentification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.Engineering synthetic recursive pathways to generate non-natural small molecules.Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus.The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.The enzymology of combinatorial biosynthesis.A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate.Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities.Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Combinatorial biosynthesis of reduced polyketides.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.The type I fatty acid and polyketide synthases: a tale of two megasynthasesMechanism and specificity of an acyltransferase domain from a modular polyketide synthaseCloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis.Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.Structural analysis of protein-protein interactions in type I polyketide synthasesRevisiting the modularity of modular polyketide synthases.Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.Polyketide stereocontrol: a study in chemical biology.Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.Mupirocin: biosynthesis, special features and applications of an antibiotic from a gram-negative bacterium.Protein engineering towards natural product synthesis and diversification.The structures of type I polyketide synthases.Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases.Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones.An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units.
P2860
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P2860
Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Alteration of the substrate sp ...... rough site-specific mutations.
@ast
Alteration of the substrate sp ...... rough site-specific mutations.
@en
type
label
Alteration of the substrate sp ...... rough site-specific mutations.
@ast
Alteration of the substrate sp ...... rough site-specific mutations.
@en
prefLabel
Alteration of the substrate sp ...... rough site-specific mutations.
@ast
Alteration of the substrate sp ...... rough site-specific mutations.
@en
P2093
P356
P1433
P1476
Alteration of the substrate sp ...... rough site-specific mutations.
@en
P2093
Hutchinson CR
McDaniel R
Piagentini M
P304
15464-15470
P356
10.1021/BI015864R
P407
P577
2001-12-01T00:00:00Z