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Leveraging structure for enzyme function prediction: methods, opportunities, and challengesThe Missing Linker: A Dimerization Motif Located within Polyketide Synthase ModulesStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryStructure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetryA Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide SynthaseStructural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreductionA Double-Hotdog with a New Trick: Structure and Mechanism of the trans -Acyltransferase Polyketide Synthase Enoyl-isomeraseVinylogous chain branching catalysed by a dedicated polyketide synthase moduleDomain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferaseUsing modern tools to probe the structure-function relationship of fatty acid synthasesArchitecture of the polyketide synthase module: surprises from electron cryo-microscopyCharacterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreusCharacterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthaseStructural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein.Portability and Structure of the Four-Helix Bundle Docking Domains of trans-Acyltransferase Modular Polyketide Synthases.Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds.Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseGenome-guided insights into the versatile metabolic capabilities of the mercaptosuccinate-utilizing β-proteobacterium Variovorax paradoxus strain B4.Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloadditionEnediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyMolecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity.Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans.Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASEA computationally simplistic poly-phasic approach to explore microbial communities from the Yucatan aquifer as a potential sources of novel natural products.The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Rational reprogramming of fungal polyketide first-ring cyclizationα-Methylation follows condensation in the gephyronic acid modular polyketide synthaseMethyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates.Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.Structural analysis of protein-protein interactions in type I polyketide synthasesDraft genome sequence of Streptomyces sp. TP-A0867, an alchivemycin producer.Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry.Emerging trends in the discovery of natural product antibacterials.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The structures of type I polyketide synthases.
@en
type
label
The structures of type I polyketide synthases.
@en
prefLabel
The structures of type I polyketide synthases.
@en
P2860
P356
P1476
The structures of type I polyketide synthases.
@en
P2093
Adrian T Keatinge-Clay
P2860
P304
P356
10.1039/C2NP20019H
P577
2012-08-03T00:00:00Z