Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. - Wikidata - wikimedia - TriplyDB

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

http://www.wikidata.org/entity/Q37282449

about

The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica Lessons from the past and charting the future of marine natural products drug discovery and chemical biology Complexity generation during natural product biosynthesis using redox enzymes Unusual carbon fixation gives rise to diverse polyketide extender units Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.Natural products version 2.0: connecting genes to molecules.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling.Insights from the sea: structural biology of marine polyketide synthases The enzymes of β-lactam biosynthesis.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models Genomic basis for natural product biosynthetic diversity in the actinomycetes A sea of biosynthesis: marine natural products meet the molecular age.Biosynthesis of akaeolide and lorneic acids and annotation of type I polyketide synthase gene clusters in the genome of Streptomyces sp. NPS554.Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.Evolution of secondary metabolite genes in three closely related marine actinomycete species Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins.Reinvigorating natural product combinatorial biosynthesis with synthetic biology Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting.Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.Challenges and triumphs to genomics-based natural product discovery Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora.Carboxylases in natural and synthetic microbial pathways Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.Antagonistic interactions mediated by marine bacteria: the role of small molecules.Functional diversity of organic molecule enzyme cofactors.Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.

P2860

Q24599741-EFDFAE1D-F2C1-4825-8A0B-67A9695C46E5 Q24646019-2A6E3B65-6463-478D-A89C-5B621E9FA7AC Q26863108-3ECF7F53-43E5-443B-A9F1-0ADC8BD82856 Q27000500-F97A5B9A-A01A-401A-9821-8CA40CE664D1 Q27675936-4DC1EEEA-566E-4B38-BAB5-99DE64360009 Q27678720-4380B2F2-A8DA-426F-A1F7-AF41B7B38875 Q27702125-989A238F-3855-48DA-8FA0-22169A3FAA01 Q33700902-C541EA70-AC3D-4419-B579-992FA5AC056A Q34096062-899C7F4E-1AF5-44BA-B6EC-55E279390B05 Q34142223-051D1FF6-3289-406F-A01E-E9F927133C92 Q34173936-AF396035-D01C-40CC-B9E5-4E7A882F1F34 Q34222047-6BCBEF5A-849C-42DB-8113-7C0C2871DD0C Q34231950-3E553201-8564-4D0D-ACF4-46B61C34AE3D Q34267983-AFDBD544-EA85-4893-9FCE-C26AB8618807 Q34310470-AA1BE6A6-0408-4F02-917F-A5574514100A Q34465208-1282749D-0445-4907-BEC1-4FEA489B54D1 Q34538163-B991E033-BF28-449E-AF49-B5B90B66C5A0 Q34700983-9382121A-A449-45AC-8D8C-129B7D0A3961 Q34711979-2C676F9D-9ADF-45CC-A5AC-CBBB75C94776 Q35006338-7C355B1B-6AC6-40B0-A535-E221FCAE48FD Q35015405-D2449B82-6B1E-414F-A608-2BFFD966B19C Q35088943-69E6234D-C2B1-4F92-AED4-B24B4D4B3860 Q35362075-9C20C92A-4BF4-491C-9F64-49E963065431 Q35538609-48253B2A-8C6C-46F2-A23E-26229A8DAD5F Q35634544-D3E85704-C59D-44B5-9564-BC31B7AEA13C Q35780235-16524C8E-46A3-4D8E-B652-0C54F414D2F5 Q36482701-56003C08-F7D4-47F9-80D2-A3BCB36053A5 Q36590659-078DF8B6-EE92-4658-B7DC-298E6F6DE64D Q36741597-5C13502B-2261-4941-8301-A38E389F4786 Q37017342-A6032685-5FCC-47B0-9555-628B5FA53220 Q37028302-F08DBE83-6DF1-4898-A1FB-D20EDDF211D8 Q37331323-B48226A1-4EF7-4F39-B7F6-01F6B60E1FCF Q37533520-6DC8C33C-535C-46EB-AF08-CB0C35B09DFF Q37625408-119869F4-4A80-405D-9725-B85C058307E0 Q37674497-42D0DF0C-5523-4683-9DBC-C8FE6CC8894B Q37946335-5667E9BD-78E3-48CB-B414-E125F1F72235 Q37962381-EDF219E1-8828-4302-982A-C7FDC0EA39FD Q38121455-AB8516A8-1B0F-4CBD-9765-E889D3FAAEF8 Q38128203-6E0149F7-B5DC-47A2-9D19-15BB8FF00578 Q38156708-E8CD5B13-FCAD-4363-8C2B-43C0516562F0

P2860

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

http://www.wikidata.org/entity/Q37282449

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 09 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@en

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@nl

type

label

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@en

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@nl

prefLabel

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@en

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@nl

P1433

Q37282449-BAC67DB5-FCEE-4BC6-8B13-B11164952FB3

P1476

Q37282449-ED55D662-D092-4F43-9F9C-9694D76A2CF6

P2093

Q37282449-098FC85A-100A-46C0-852D-747D547D7CEC

Q37282449-0DE4E25B-AEA6-4104-B683-0B7CC64887CF

Q37282449-12C239D5-916E-4F12-BE92-7341330307CA

Q37282449-169C8C41-8326-4258-88B6-ED1DCBF976E3

Q37282449-1761004D-C505-47A8-AC16-5E3C4727510C

Q37282449-33A94519-89DD-4CC3-99E4-DD8B254F1326

Q37282449-513BDD1E-B959-45E9-A5AC-B102FD284A2E

Q37282449-6D694019-D98E-4528-B984-A9F184124708

Q37282449-A1F05F0E-85DA-4DBE-9FA3-B06A090C35F3

Q37282449-AD5EEA2D-01D1-4082-9D28-2205359E1805

P2860

Q37282449-0801C9C1-368C-4748-A77C-CD5A1B7A0FE9

Q37282449-1404E73C-892C-4C5C-962D-E03E06A7FAA7

Q37282449-18006091-8EEC-4F79-B33B-508D2F7A2AF6

Q37282449-1C64CDC7-5DD2-4712-889F-6476FC456041

Q37282449-28A21C2C-D6CE-40E2-9B1A-E79A47CE3B19

Q37282449-2EC7E6B5-B259-4A54-9C71-6C39C22FA8E8

Q37282449-3CEF10D1-C4C9-42D0-A1FB-F7CAEDDDA80B

Q37282449-3DD43833-46EF-421A-85CA-FE3816AC835F

Q37282449-415A3A35-0BE6-436A-A6B0-14BE411E9F47

Q37282449-48C25BA9-2C77-4328-A5DE-2776B2809A51

P304

Q37282449-2BDEAD3A-FFF6-44E7-9183-196FA7F635C7

P31

Q37282449-323B4D0E-6147-4572-80C2-E408578162F9

P356

Q37282449-8617617D-1FD3-4A2A-A791-04445929BA75

P407

Q37282449-28E4243A-75FE-4512-91D5-009620C0C878

P433

Q37282449-5EC58621-3F67-4D6B-AF5A-07ADA98C40FF

P478

Q37282449-EB96C574-2882-4F76-896A-A6011FE43189

P577

Q37282449-1AF8A372-D262-40CA-80CF-5381B0532156

P5875

Q37282449-497502FA-ABF4-4513-BE89-8FB5CFC6A1F3

P698

Q37282449-57600581-DCE3-4561-8478-B725DD625198

P932

Q37282449-F9683BF1-F294-4948-8142-F167E2309B53

P356

PNAS.0901237106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Biosynthesis of the salinospor ...... from S-adenosyl-L-methionine.

@en

P2093

Alessandra S Eustáquio

http://www.w3.org/2001/XMLSchema#string

Andrew J Kale

http://www.w3.org/2001/XMLSchema#string

Anna Lechner

http://www.w3.org/2001/XMLSchema#string

Bradley S Moore

http://www.w3.org/2001/XMLSchema#string

Christopher Hazzard

http://www.w3.org/2001/XMLSchema#string

Galina Florova

http://www.w3.org/2001/XMLSchema#string

Kevin A Reynolds

http://www.w3.org/2001/XMLSchema#string

Laura L Beer

http://www.w3.org/2001/XMLSchema#string

Mamoun M Alhamadsheh

http://www.w3.org/2001/XMLSchema#string

Ryan P McGlinchey

http://www.w3.org/2001/XMLSchema#string

P2860

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate

Crystal structure and mechanism of a bacterial fluorinating enzyme

Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

The chalcone synthase superfamily of type III polyketide synthases

Evolution of polyketide synthases in bacteria

Structural analyses reveal two distinct families of nucleoside phosphorylases

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis

P304

12295-12300

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0901237106

http://www.w3.org/2001/XMLSchema#string

P407

P433

30

http://www.w3.org/2001/XMLSchema#string

P478

106

http://www.w3.org/2001/XMLSchema#string

P577

2009-07-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26659100

http://www.w3.org/2001/XMLSchema#string

P698

19590008

http://www.w3.org/2001/XMLSchema#string

P932

2718359

http://www.w3.org/2001/XMLSchema#string