Inactivation of the mouse Huntington's disease gene homolog Hdh
about
Ubiquitin-proteasome system involvement in Huntington's diseaseMood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsHuntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaHuntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsHuntingtin promotes cell survival by preventing Pak2 cleavageA human HAP1 homologue. Cloning, expression, and interaction with huntingtinHuntingtin in health and diseaseMultiple Aspects of Gene Dysregulation in Huntington's DiseaseCongenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineagesPreclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's diseaseHuman single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's diseaseCAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroupTransgenic models of Huntington's diseaseReversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregationInactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.Neural and mesenchymal stem cells in animal models of Huntington's disease: past experiences and future challengesIron dysregulation in Huntington's diseaseHuntington's disease: the past, present, and future search for disease modifiers.Transgenic animal models for study of the pathogenesis of Huntington's disease and therapyModeling Huntington's disease with induced pluripotent stem cellsThe N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolismDeficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideumAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachHuntingtin functions as a scaffold for selective macroautophagyExpression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin IINormal huntingtin function: an alternative approach to Huntington's diseaseShaping the role of mitochondria in the pathogenesis of Huntington's diseaseGenetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesisCellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic miceDeletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroAllele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patientsHuntingtin inhibits caspase-3 activationMutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroA Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in miceThe gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 familyPotential function for the Huntingtin protein as a scaffold for selective autophagy.Is Huntingtin Dispensable in the Adult Brain?Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro.Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.
P2860
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P2860
Inactivation of the mouse Huntington's disease gene homolog Hdh
description
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1995
@ast
im Juli 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/07/21)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/07/21)
@nl
наукова стаття, опублікована в липні 1995
@uk
name
Inactivation of the mouse Huntington's disease gene homolog Hdh
@ast
Inactivation of the mouse Huntington's disease gene homolog Hdh
@en
Inactivation of the mouse Huntington's disease gene homolog Hdh
@nl
type
label
Inactivation of the mouse Huntington's disease gene homolog Hdh
@ast
Inactivation of the mouse Huntington's disease gene homolog Hdh
@en
Inactivation of the mouse Huntington's disease gene homolog Hdh
@nl
prefLabel
Inactivation of the mouse Huntington's disease gene homolog Hdh
@ast
Inactivation of the mouse Huntington's disease gene homolog Hdh
@en
Inactivation of the mouse Huntington's disease gene homolog Hdh
@nl
P2093
P3181
P356
P1433
P1476
Inactivation of the mouse Huntington's disease gene homolog Hdh
@en
P2093
A. B. Auerbach
A. L. Joyner
F. Persichetti
G. T. Barnes
J. P. Vonsattel
M. P. Duyao
S. M. McNeil
P304
P3181
P356
10.1126/SCIENCE.7618107
P407
P577
1995-07-21T00:00:00Z