The design, structures and therapeutic potential of protein epitope mimetics.
about
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motifSynthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclizationPeptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosaMiniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic responseMax Bergmann lecture protein epitope mimetics in the age of structural vaccinologyNon-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries.The design and application of target-focused compound libraries.Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides.Small molecule inhibitors of CXCR4.Synthetic mimetics of protein secondary structure domainsDesigner macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation.Structural characterization and in vivo evaluation of β-Hairpin peptidomimetics as specific CXCR4 imaging agentsExpanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines.A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases.Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALLCXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches.Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma.KLK-targeted Therapies for Prostate Cancer.Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.New agents in HSC mobilization.Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.PEP-SiteFinder: a tool for the blind identification of peptide binding sites on protein surfaces.Ultrafast folding and molecular dynamics of a linear hydrophobic β-hairpin.Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction.Conformational stabilization of a β-hairpin through a triazole-tryptophan interaction.Analysis of designed β-hairpin peptides: molecular conformation and packing in crystals.Virtual screening for compounds that mimic protein-protein interface epitopes.Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation.Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation
P2860
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P2860
The design, structures and therapeutic potential of protein epitope mimetics.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The design, structures and therapeutic potential of protein epitope mimetics.
@ast
The design, structures and therapeutic potential of protein epitope mimetics.
@en
type
label
The design, structures and therapeutic potential of protein epitope mimetics.
@ast
The design, structures and therapeutic potential of protein epitope mimetics.
@en
prefLabel
The design, structures and therapeutic potential of protein epitope mimetics.
@ast
The design, structures and therapeutic potential of protein epitope mimetics.
@en
P2093
P1433
P1476
The design, structures and therapeutic potential of protein epitope mimetics.
@en
P2093
Daniel Obrecht
Frank Gombert
John A Robinson
Kerstin Moehle
Steve Demarco
P304
P356
10.1016/J.DRUDIS.2008.07.008
P577
2008-09-11T00:00:00Z