Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases - Wikidata - wikimedia - TriplyDB

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

http://www.wikidata.org/entity/Q30419941

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Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation Genetics of rheumatoid arthritis contributes to biology and drug discovery Seasonal Variations of Complete Blood Count and Inflammatory Biomarkers in the US Population - Analysis of NHANES Data Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma.The impact of rare and low-frequency genetic variants in common disease Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy.Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target.A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.Widespread seasonal gene expression reveals annual differences in human immunity and physiology Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10.Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6.Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins.Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment.Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Identification of STOML2 as a putative novel asthma risk gene associated with IL6R.Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population.Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation.The rs2228145 polymorphism in the interleukin-6 receptor and its association with long-term prognosis after myocardial infarction in a pilot study.The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome.Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1 The use of monoclonal antibodies to treat Castleman's disease.IL-6 biology: implications for clinical targeting in rheumatic disease.Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles Immune-mediated mechanisms of atherosclerosis and implications for the clinic.Interleukin-6 "Trans-Signaling" and Ischemic Vascular Disease: The Important Role of Soluble gp130.The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation.A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register.

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P2860

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

http://www.wikidata.org/entity/Q30419941

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Functional IL6R 358Ala allele ...... diverse inflammatory diseases

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Functional IL6R 358Ala allele ...... diverse inflammatory diseases

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type

label

Functional IL6R 358Ala allele ...... diverse inflammatory diseases

@ast

Functional IL6R 358Ala allele ...... diverse inflammatory diseases

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prefLabel

Functional IL6R 358Ala allele ...... diverse inflammatory diseases

@ast

Functional IL6R 358Ala allele ...... diverse inflammatory diseases

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JOURNAL.PGEN.1003444

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Functional IL6R 358Ala allele ...... diverse inflammatory diseases

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Charlotte Boreham

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Daniel B Rainbow

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Daniel F Freitag

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Joanna M M Howson

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John Danesh

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Marcin L Pekalski

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Pamela Clarke

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Ricardo C Ferreira

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Richard M Coulson

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Stephen Kaptoge

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P2860

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

Th17 and regulatory T cells in mediating and restraining inflammation.

IL-17 and Th17 Cells

A new mathematical model for relative quantification in real-time RT-PCR

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review

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e1003444

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4

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9

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Suna Onengut-Gumuscu

Adam S. Butterworth

Antony J Cutler

Anders Malarstig

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2013-04-04T00:00:00Z

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236207408

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23593036

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3617094

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