Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. - Wikidata - wikimedia - TriplyDB

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

http://www.wikidata.org/entity/Q30425491

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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases Multiple Roles of the Small GTPase Rab7 Alterations in Mitochondrial Quality Control in Alzheimer's Disease Axonal transport: cargo-specific mechanisms of motility and regulation The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration Eaten alive: novel insights into autophagy from multicellular model systems The pathways of mitophagy for quality control and clearance of mitochondria Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport.Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes.Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves in vivo α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons Spatial and temporal characteristics of normal and perturbed vesicle transport Mitochondrial fission is an acute and adaptive response in injured motor neurons Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics Autophagosome dynamics in neurodegeneration at a glance Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation Functions and mechanics of dynein motor proteins Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway Early and sustained activation of autophagy in degenerating axons after spinal cord injury The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions Harnessing the power of the endosome to regulate neural development.Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Mechanism and regulation of cytoplasmic dynein Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury.Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

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P2860

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

http://www.wikidata.org/entity/Q30425491

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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name

Autophagosomes initiate distal ...... cell soma in primary neurons.

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Autophagosomes initiate distal ...... cell soma in primary neurons.

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Autophagosomes initiate distal ...... cell soma in primary neurons.

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Autophagosomes initiate distal ...... cell soma in primary neurons.

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Autophagosomes initiate distal ...... cell soma in primary neurons.

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P2093

Erika L F Holzbaur

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Karen E Wallace

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Sandra Maday

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P2860

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Dynactin is required for microtubule anchoring at centrosomes

Autophagy fights disease through cellular self-digestion

The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Loss of autophagy in the central nervous system causes neurodegeneration in mice

In vitro reconstitution of fusion between immature autophagosomes and endosomes

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407-417

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10.1083/JCB.201106120

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4

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196

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2012-02-13T00:00:00Z

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221830059

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22331844

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