AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex
about
Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular levelLafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolismLaforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cellsCo-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease.Protein degradation and quality control in cells from laforin and malin knockout mice.A PTG variant contributes to a milder phenotype in Lafora diseaseLafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional levelGenetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforinMinireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system.Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogsDimerization of the glucan phosphatase laforin requires the participation of cysteine 329.The extended PP1 toolkit: designed to create specificity.The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation.The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters.Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease.Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell deathDeciphering the role of malin in the lafora progressive myoclonus epilepsyHigh NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1.Glycogen and its metabolism: some new developments and old themes.Glycogen: an overview of possible regulatory roles of the proteins associated with the granule.Lafora disease: insights into neurodegeneration from plant metabolism.Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylaseThe regulation of muscle glycogen: the granule and its proteins.The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.Glycogen hyperphosphorylation underlies lafora body formation.The Laforin-like dual-specificity phosphatase SEX4 from Arabidopsis hydrolyzes both C6- and C3-phosphate esters introduced by starch-related dikinases and thereby affects phase transition of alpha-glucans.Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.AMPK Protein Interaction Analyses by Yeast Two-Hybrid.
P2860
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P2860
AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex
description
2009 nî lūn-bûn
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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2009 թվականի հունվարին հրատարակված գիտական հոդված
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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name
AMP-activated protein kinase p ...... n by the laforin-malin complex
@ast
AMP-activated protein kinase p ...... n by the laforin-malin complex
@en
type
label
AMP-activated protein kinase p ...... n by the laforin-malin complex
@ast
AMP-activated protein kinase p ...... n by the laforin-malin complex
@en
prefLabel
AMP-activated protein kinase p ...... n by the laforin-malin complex
@ast
AMP-activated protein kinase p ...... n by the laforin-malin complex
@en
P2093
P2860
P50
P356
P1476
AMP-activated protein kinase p ...... n by the laforin-malin complex
@en
P2093
José Vicente Gimeno-Alcañiz
Luisa García-Haro
M Carmen Solaz-Fuster
Teresa Rubio
P2860
P304
P356
10.1074/JBC.M808492200
P407
P577
2009-01-26T00:00:00Z