Cellular characterization of a novel focal adhesion kinase inhibitor. - Wikidata - wikimedia - TriplyDB

Cellular characterization of a novel focal adhesion kinase inhibitor.

Cellular characterization of a novel focal adhesion kinase inhibitor.

http://www.wikidata.org/entity/Q30443304

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The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors FAK and paxillin, two potential targets in pancreatic cancer Identifying new small molecule anti-invasive compounds for glioma treatment FAK in cancer: mechanistic findings and clinical applications The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin.Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes Cortactin as a target for FAK in the regulation of focal adhesion dynamics LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Focal adhesions control cleavage furrow shape and spindle tilt during mitosis Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration.Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner Discovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular docking Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model Focal adhesion kinase as a regulator of cell tension in the progression of cancer.Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues Netrin-1 attracts axons through FAK-dependent mechanotransduction TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner.Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin.Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines.

P2860

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P2860

Cellular characterization of a novel focal adhesion kinase inhibitor.

http://www.wikidata.org/entity/Q30443304

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

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2007年论文

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name

Cellular characterization of a novel focal adhesion kinase inhibitor.

@ast

Cellular characterization of a novel focal adhesion kinase inhibitor.

@en

type

label

Cellular characterization of a novel focal adhesion kinase inhibitor.

@ast

Cellular characterization of a novel focal adhesion kinase inhibitor.

@en

prefLabel

Cellular characterization of a novel focal adhesion kinase inhibitor.

@ast

Cellular characterization of a novel focal adhesion kinase inhibitor.

@en

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P1433

Journal of Biological Chemistry

P1476

Cellular characterization of a novel focal adhesion kinase inhibitor.

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P2093

Beth Cooper

http://www.w3.org/2001/XMLSchema#string

Christopher Autry

http://www.w3.org/2001/XMLSchema#string

Ethan J Ung

http://www.w3.org/2001/XMLSchema#string

J Thomas Parsons

http://www.w3.org/2001/XMLSchema#string

Jill K Slack-Davis

http://www.w3.org/2001/XMLSchema#string

John C Kath

http://www.w3.org/2001/XMLSchema#string

Karen H Martin

http://www.w3.org/2001/XMLSchema#string

Marcin Iwanicki

http://www.w3.org/2001/XMLSchema#string

Michael J Luzzio

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Robert W Tilghman

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P304

14845-14852

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scholarly article

P356

10.1074/JBC.M606695200

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P433

20

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P478

282

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2007-03-28T00:00:00Z

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P698

17395594

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