Cellular characterization of a novel focal adhesion kinase inhibitor.
about
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophilsNuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationNeuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cellsIntegrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumorsFAK and paxillin, two potential targets in pancreatic cancerIdentifying new small molecule anti-invasive compounds for glioma treatmentFAK in cancer: mechanistic findings and clinical applicationsThe FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin.Altering FAK-paxillin interactions reduces adhesion, migration and invasion processesCortactin as a target for FAK in the regulation of focal adhesion dynamicsLRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Focal adhesions control cleavage furrow shape and spindle tilt during mitosisSubstrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectinRegulation of invasive behavior by vascular endothelial growth factor is HEF1-dependentForce fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration.Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung CancerHeparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagenDecreased cell adhesion promotes angiogenesis in a Pyk2-dependent mannerDiscovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular dockingAdhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate modelFocal adhesion kinase as a regulator of cell tension in the progression of cancer.Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinaseKnock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinaseDetection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transferFocal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cuesNetrin-1 attracts axons through FAK-dependent mechanotransductionTRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner.Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin.Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signalingIntrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines.
P2860
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P2860
Cellular characterization of a novel focal adhesion kinase inhibitor.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cellular characterization of a novel focal adhesion kinase inhibitor.
@ast
Cellular characterization of a novel focal adhesion kinase inhibitor.
@en
type
label
Cellular characterization of a novel focal adhesion kinase inhibitor.
@ast
Cellular characterization of a novel focal adhesion kinase inhibitor.
@en
prefLabel
Cellular characterization of a novel focal adhesion kinase inhibitor.
@ast
Cellular characterization of a novel focal adhesion kinase inhibitor.
@en
P2093
P356
P1476
Cellular characterization of a novel focal adhesion kinase inhibitor.
@en
P2093
Beth Cooper
Christopher Autry
Ethan J Ung
J Thomas Parsons
Jill K Slack-Davis
John C Kath
Karen H Martin
Marcin Iwanicki
Michael J Luzzio
Robert W Tilghman
P304
14845-14852
P356
10.1074/JBC.M606695200
P407
P577
2007-03-28T00:00:00Z