Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
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FAK promotes recruitment of talin to nascent adhesions to control cell motilityTips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesisNuclear FAK: a new mode of gene regulation from cellular adhesionsNormal morphogenesis of epithelial tissues and progression of epithelial tumors.FAK in cancer: mechanistic findings and clinical applicationsRgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrinsCortactin as a target for FAK in the regulation of focal adhesion dynamicsPhosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changesFAK is required for tension-dependent organization of collective cell movements in Xenopus mesendodermMyosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsThe C terminus of talin links integrins to cell cycle progression.Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.VEGF-induced vascular permeability is mediated by FAK.FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expressionLKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistenceDisrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsA non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase.Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes.Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence.Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices.Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.Focal adhesion kinase and tumour angiogenesis.System-based drug discovery within the human kinome.Targeting FAK in human cancer: from finding to first clinical trials.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.Molecular Pathways: Endothelial Cell FAK-A Target for Cancer Treatment.Generation of point-mutant FAK knockin mice.Focal adhesion kinase signaling in unexpected places.Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.Integrin adhesions: who's on first? What's on second? Connections between FAK and talin.
P2860
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P2860
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@ast
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@en
type
label
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@ast
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@en
prefLabel
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@ast
Knock-in mutation reveals an e ...... ty but not cell proliferation.
@en
P2093
P2860
P356
P1476
Knock-in mutation reveals an e ...... ity but not cell proliferation
@en
P2093
Alok Tomar
David D Schlaepfer
Jiyeon Yoo
Nichol L G Miller
Xiao Lei Chen
P2860
P304
21526-21536
P356
10.1074/JBC.M110.129999
P407
P577
2010-05-04T00:00:00Z