Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
about
In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human isletsIA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional networkGenetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cellsDachshund homologues play a conserved role in islet cell developmentRole of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS.Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.Insulin gene expression is regulated by DNA methylationIdentification of known and novel pancreas genes expressed downstream of Nkx2.2 during developmentHMGN5/NSBP1: a new member of the HMGN protein family that affects chromatin structure and functionGene expression in the placenta: maternal stress and epigenetic responses.Contribution of a non-β-cell source to β-cell mass during pregnancy.Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.Direct lineage conversions: unnatural but useful?Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.Primary cilia in pancreatic development and disease.Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.The transcription factor Myt3 acts as a pro-survival factor in β-cellsA mouse model for monitoring islet cell genesis and developing therapies for diabetesExpression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells.The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.A small molecule differentiation inducer increases insulin production by pancreatic β cellsTransient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene TransductionSox9 coordinates a transcriptional network in pancreatic progenitor cellsExploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass.The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.Strategies for developing therapeutic application of human embryonic stem cells.Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lungNeurogenin3 cooperates with Foxa2 to autoactivate its own expression.Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells.Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesityChronology of islet differentiation revealed by temporal cell labeling
P2860
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P2860
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@ast
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@en
type
label
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@ast
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@en
prefLabel
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@ast
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@en
P2093
P2860
P356
P1476
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
@en
P2093
Caroline Mrejen
Juehu Wang
Michael Barnes
Michael German
Nathaniel Leachman
Raghavendra Mirmira
Swarup Chakrabarti
P2860
P304
13245-13250
P356
10.1073/PNAS.0405301101
P407
P50
P577
2004-08-30T00:00:00Z