Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities.
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Universal phosphatase-coupled glycosyltransferase assayClostridium difficile toxins: mechanism of action and role in disease.Clostridium difficile infection: molecular pathogenesis and novel therapeuticsStructural Determinants of Clostridium difficile Toxin A Glucosyltransferase ActivityThe structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product releaseSynthase-dependent exopolysaccharide secretion in Gram-negative bacteria.Characterization of the PcCdc42 small G protein from Pneumocystis carinii, which interacts with the PcSte20 life cycle regulatory kinase.Mutational analysis of the enzymatic domain of Clostridium difficile toxin B reveals novel inhibitors of the wild-type toxinClostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.Poisons, ruffles and rockets: bacterial pathogens and the host cell cytoskeleton.PseG of pseudaminic acid biosynthesis: a UDP-sugar hydrolase as a masked glycosyltransferase.Upregulation of the host SLC11A1 gene by Clostridium difficile toxin B facilitates glucosylation of Rho GTPases and enhances toxin lethality.Identification of a novel virulence factor in Clostridium difficile that modulates toxin sensitivity of cultured epithelial cells.Toward a structural understanding of Clostridium difficile toxins A and B.Biophysical Characterization and Activity of Lymphostatin, a Multifunctional Virulence Factor of Attaching and Effacing Escherichia coli.A lipid-protein hybrid model for tight junction.Super toxins from a super bug: structure and function of Clostridium difficile toxins.Total synthesis of Le(A)-LacNAc pentasaccharide as a ligand for Clostridium difficile toxin A.In vitro activity of Neisseria meningitidis PglL O-oligosaccharyltransferase with diverse synthetic lipid donors and a UDP-activated sugar.Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function.Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways.Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.Analysis of the polymerization initiation and activity of Pasteurella multocida heparosan synthase PmHS2, an enzyme with glycosyltransferase and UDP-sugar hydrolase activity.Harnessing the glucosyltransferase activities of Clostridium difficile for functional studies of toxins A and B.R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile.Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile.Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.Treatment of Clostridium difficile infection with a small molecule inhibitor of toxin UDP-glucose hydrolysis activity.Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells.Three new Nudix hydrolases from Escherichia coli.
P2860
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P2860
Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Clostridium difficile toxins A ...... iffering catalytic activities.
@ast
Clostridium difficile toxins A ...... iffering catalytic activities.
@en
type
label
Clostridium difficile toxins A ...... iffering catalytic activities.
@ast
Clostridium difficile toxins A ...... iffering catalytic activities.
@en
prefLabel
Clostridium difficile toxins A ...... iffering catalytic activities.
@ast
Clostridium difficile toxins A ...... iffering catalytic activities.
@en
P2860
P356
P1476
Clostridium difficile toxins A ...... iffering catalytic activities.
@en
P2093
Ciesla WP Jr
P2860
P304
16021-16026
P356
10.1074/JBC.273.26.16021
P407
P577
1998-06-01T00:00:00Z