Hexameric ring structure of the full-length archaeal MCM protein complex.
about
Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiaeHexameric ring structure of human MCM10 DNA replication factorFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Conserved nucleosome positioning defines replication originsConcerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensingPreventing re-replication of chromosomal DNA.DNA replication in the archaeaDNA binding and helicase actions of mouse MCM4/6/7 helicase.Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties.Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2-7 Helicase to Reveal Essential Features of Structure and FunctionMechanisms for initiating cellular DNA replicationThe minichromosome maintenance replicative helicaseMCM ring hexamerization is a prerequisite for DNA-binding.Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domainStructure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm ProteinsA conserved MCM single-stranded DNA binding element is essential for replication initiationDifferences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.Origin recognition and the chromosome cycleThe structural basis for MCM2-7 helicase activation by GINS and Cdc45.Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complexMutations in subdomain B of the minichromosome maintenance (MCM) helicase affect DNA binding and modulate conformational transitionsTwo heads are better than one: regulation of DNA replication by hexameric helicasesCMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.Evolution of DNA replication protein complexes in eukaryotes and Archaea.A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNAStructural insights into the Cdt1-mediated MCM2-7 chromatin loading.The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.Molecular architecture of a multifunctional MCM complexS-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Minichromosome maintenance helicase activity is controlled by N- and C-terminal motifs and requires the ATPase domain helix-2 insert.Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zoneCharacterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus.Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding.Analysis of the crystal structure of an active MCM hexamerDNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase.
P2860
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P2860
Hexameric ring structure of the full-length archaeal MCM protein complex.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Hexameric ring structure of the full-length archaeal MCM protein complex.
@ast
Hexameric ring structure of the full-length archaeal MCM protein complex.
@en
type
label
Hexameric ring structure of the full-length archaeal MCM protein complex.
@ast
Hexameric ring structure of the full-length archaeal MCM protein complex.
@en
prefLabel
Hexameric ring structure of the full-length archaeal MCM protein complex.
@ast
Hexameric ring structure of the full-length archaeal MCM protein complex.
@en
P2093
P2860
P356
P1433
P1476
Hexameric ring structure of the full-length archaeal MCM protein complex.
@en
P2093
Giorgia Vicentini
Hedije Meka
Marin van Heel
Shaoxia Chen
P2860
P304
P356
10.1038/SJ.EMBOR.7400010
P577
2003-10-17T00:00:00Z