Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.
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Evolution of minimal specificity and promiscuity in steroid hormone receptorsEvolution favors protein mutational robustness in sufficiently large populationsIn the light of directed evolution: pathways of adaptive protein evolutionExploring protein fitness landscapes by directed evolutionThe role of robustness in phenotypic adaptation and innovationThe Generation and Exploitation of Protein Mutability Landscapes for Enzyme EngineeringEnvironmental changes bridge evolutionary valleysEvolutionary plasticity and innovations in complex metabolic reaction networksDNA polymerases engineered by directed evolution to incorporate non-standard nucleotidesA nonadaptive origin of a beneficial trait: in silico selection for free energy of folding leads to the neutral emergence of mutational robustness in single domain proteins.The virtue of innovation: innovation through the lenses of biological evolutionDynamic New World: Refining Our View of Protein Structure, Function and EvolutionDistribution of genotype network sizes in sequence-to-structure genotype-phenotype maps.Directed enzyme evolution via small and effective neutral drift libraries.Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encodedTherapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral driftCauses of molecular convergence and parallelism in protein evolution.Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant.Mining endonuclease cleavage determinants in genomic sequence data.Patterns of positive selection and neutral evolution in the protein-coding genes of Tetraodon and Takifugu.Improved modeling of side-chain--base interactions and plasticity in protein--DNA interface designProbing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approachEvolutionary biochemistry: revealing the historical and physical causes of protein properties.Differential effects of a mutation on the normal and promiscuous activities of orthologs: implications for natural and directed evolution.Mutagenic Organized Recombination Process by Homologous IN vivo Grouping (MORPHING) for directed enzyme evolution.Origins of specificity and promiscuity in metabolic networks.Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.AAV ancestral reconstruction library enables selection of broadly infectious viral variants.Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates.Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.Principal component analysis of CYP2C9 and CYP3A4 probe substrate/inhibitor panels.Directed enzyme evolution: climbing fitness peaks one amino acid at a time.Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Mutational robustness accelerates the origin of novel RNA phenotypes through phenotypic plasticity.Markers of fitness in a successful enzyme superfamily.P450(BM3) (CYP102A1): connecting the dots.Computational enzyme design.Dynamics and constraints of enzyme evolution.
P2860
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P2860
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Neutral genetic drift can alte ...... y aiding functional evolution.
@ast
Neutral genetic drift can alte ...... y aiding functional evolution.
@en
type
label
Neutral genetic drift can alte ...... y aiding functional evolution.
@ast
Neutral genetic drift can alte ...... y aiding functional evolution.
@en
prefLabel
Neutral genetic drift can alte ...... y aiding functional evolution.
@ast
Neutral genetic drift can alte ...... y aiding functional evolution.
@en
P2860
P356
P1433
P1476
Neutral genetic drift can alte ...... y aiding functional evolution.
@en
P2093
Philip A Romero
Zhongyi Lu
P2860
P2888
P356
10.1186/1745-6150-2-17
P577
2007-06-28T00:00:00Z
P5875
P6179
1013211276