GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases - Wikidata - wikimedia - TriplyDB

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

http://www.wikidata.org/entity/Q30480028

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The emerging importance of group II PAKs Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.Cyclin A2: At the crossroads of cell cycle and cell invasion Phosphorylation-mediated regulation of GEFs for RhoA The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells Foci of cyclin A2 interact with actin and RhoA in mitosis.PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.MPF governs the assembly and contraction of actomyosin rings by activating RhoA and MAPK during chemical-induced cytokinesis of goat oocytes Midbody localization of Vinexin recruits Rhotekin to facilitate cytokinetic abscission.Epithelial junctions and Rho family GTPases: the zonular signalosome.The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells.Regulation of cytokinesis by Rho GTPase flux.LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics.Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells.GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle.Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle.RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1 Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.Action at a distance during cytokinesis.Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.The incredible journey: From megakaryocyte development to platelet formation.Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon

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P2860

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

http://www.wikidata.org/entity/Q30480028

description

2007 nî lūn-bûn

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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

GEF-H1 modulates localized Rho ...... the control of mitotic kinases

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GEF-H1 modulates localized Rho ...... the control of mitotic kinases

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type

label

GEF-H1 modulates localized Rho ...... the control of mitotic kinases

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GEF-H1 modulates localized Rho ...... the control of mitotic kinases

@en

prefLabel

GEF-H1 modulates localized Rho ...... the control of mitotic kinases

@ast

GEF-H1 modulates localized Rho ...... the control of mitotic kinases

@en

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J.DEVCEL.2007.03.014

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Developmental Cell

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GEF-H1 modulates localized Rho ...... the control of mitotic kinases

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Benjamin P Bohl

http://www.w3.org/2001/XMLSchema#string

Gary M Bokoch

http://www.w3.org/2001/XMLSchema#string

Jörg Birkenfeld

http://www.w3.org/2001/XMLSchema#string

Klaus M Hahn

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Perihan Nalbant

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P2860

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis

An ECT2-centralspindlin complex regulates the localization and function of RhoA

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics

Dissecting the role of Rho-mediated signaling in contractile ring formation.

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation

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10.1016/J.DEVCEL.2007.03.014

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6342082

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17488622

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1965589

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