Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. - Wikidata - wikimedia - TriplyDB

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

http://www.wikidata.org/entity/Q30481900

about

De novo mutations in moderate or severe intellectual disability Calsequestrin 2 and arrhythmias Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence Mechanisms of altered Ca²⁺ handling in heart failure Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface Mechanisms of sudden unexplained death in epilepsy Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death.Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.Axial tubule junctions control rapid calcium signaling in atria Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions.RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias Ryanodine receptor channelopathies.Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice.Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias.Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds.Epilepsy is a risk factor for sudden cardiac arrest in the general population.The ryanodine receptor in cardiac physiology and disease.Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107 Superresolution modeling of calcium release in the heart Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications.Detection of protein S-nitrosylation with the biotin-switch technique.Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators.Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease.

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P2860

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

http://www.wikidata.org/entity/Q30481900

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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type

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

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Journal of Clinical Investigation

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Leaky Ca2+ release channel/rya ...... sudden cardiac death in mice.

@en

P2093

Andrew Bellinger

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Andrew R Marks

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Anetta Wronska

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Bi-Xing Chen

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Chris W Ward

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Gregory Morley

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Liam J Drew

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Marco Mongillo

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Nicolas Lindegger

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Robert S Kass

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P2860

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)

FK506 binding protein associated with the calcium release channel (ryanodine receptor)

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

A potassium channel mutation in neonatal human epilepsy

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity

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2230-2245

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10.1172/JCI35346

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6

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118

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2008-06-01T00:00:00Z

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18483626

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2381750

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