The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.
about
Rehydration of Polymeric, Aqueous, Biphasic System Facilitates High Throughput Cell Exclusion Patterning for Cell Migration Studiesβ-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expressionMultifaceted role of β-arrestins in inflammation and diseaseβ-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy.The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling.Roles for the type III TGF-beta receptor in human cancerBeyond desensitization: physiological relevance of arrestin-dependent signaling.Role of TGF-β receptor III localization in polarity and breast cancer progressionEctodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft modelsThe balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells.Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis.Proteomic analyses of serous and endometrioid epithelial ovarian cancers - cases studies - molecular insights of a possible histological etiology of serous ovarian cancer.BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behaviorMechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysTGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway.TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling.TβRIII Expression in Human Breast Cancer Stroma and the Role of Soluble TβRIII in Breast Cancer Associated Fibroblasts.CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through up-regulation of type III TGF-β receptor.Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.Therapeutic potential of β-arrestin- and G protein-biased agonists.Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells.β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivoThe pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.Noncanonical TGF-β signaling during mammary tumorigenesis.Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinomaThe transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors.Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis.srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.TGF-beta signalling and immunity in prostate tumourigenesis.Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes.
P2860
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P2860
The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@ast
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@en
type
label
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@ast
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@en
prefLabel
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@ast
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@en
P2860
P356
P1476
The type III TGF-beta receptor ...... -mediated activation of Cdc42.
@en
P2093
Gerard C Blobe
P2860
P304
P356
10.1073/PNAS.0812879106
P407
P577
2009-05-01T00:00:00Z