The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.
about
Regulation of ion channels by pyridine nucleotidesTPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Regulation and roles of Ca2+ stores in human spermReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+TPC: the NAADP discovery channel?Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesStaphylococcal leukotoxins trigger free intracellular Ca(2+) rise in neurones, signalling through acidic stores and activation of store-operated channelsThe PI3K p110δ regulates expression of CD38 on regulatory T cellsThe gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanismsDifferential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors.Two-Pore Channels: Lessons from Mutant Mouse ModelsADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells.Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium releaseDifferential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes.The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.Physiological roles of NAADP-mediated Ca2+ signaling.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells.Roles of cADPR and NAADP in pancreatic cells.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.Effect of bafilomycin and NAADP on membrane-associated ATPases and respiration of isolated mitochondria of the murine Nemeth-Kellner lymphoma.Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea.Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice.Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation.Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca²⁺ Release.Effects of NAD at purine receptors in isolated blood vessels.The signaling protein CD38 is essential for early embryonic development.Generation and characterization of a lysosomally targeted, genetically encoded Ca(2+)-sensor.Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".Endothelial Ca2+ Signaling and the Resistance to Anticancer Treatments: Partners in Crime.CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome.The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting.CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages.Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
P2860
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P2860
The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@ast
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@en
type
label
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@ast
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@en
prefLabel
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@ast
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@en
P2093
P2860
P356
P1476
The ecto-enzyme CD38 is a nico ...... es in pancreatic acinar cells.
@en
P2093
Alexis Menteyne
Frances E Lund
François Cosker
Jose-Manuel Cancela
Michiko Yamasaki
Nathalie Cheviron
P2860
P304
38251-38259
P356
10.1074/JBC.M110.125864
P407
P577
2010-09-24T00:00:00Z