Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.
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Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degenerationAxon degeneration: Molecular mechanisms of a self-destruction pathwayDeath Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degenerationAxonal transport plays a crucial role in mediating the axon-protective effects of NmNATReducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathyChemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.SARM1 activation triggers axon degeneration locally via NAD⁺ destructionLocal axonal protection by WldS as revealed by conditional regulation of protein stability.Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in DrosophilaNMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.NMNATs, evolutionarily conserved neuronal maintenance factors.Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor.MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.Concepts for regulation of axon integrity by enwrapping glia.Diverse cellular and molecular modes of axon degeneration.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Signaling mechanisms regulating Wallerian degeneration.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.Mechanisms of distal axonal degeneration in peripheral neuropathies.Molecular mechanisms in the initiation phase of Wallerian degeneration.The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.The axon-protective WLD(S) protein partially rescues mitochondrial respiration and glycolysis after axonal injury.WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.
P2860
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P2860
Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Axonal degeneration is blocked ...... duction into transected axons.
@ast
Axonal degeneration is blocked ...... duction into transected axons.
@en
type
label
Axonal degeneration is blocked ...... duction into transected axons.
@ast
Axonal degeneration is blocked ...... duction into transected axons.
@en
prefLabel
Axonal degeneration is blocked ...... duction into transected axons.
@ast
Axonal degeneration is blocked ...... duction into transected axons.
@en
P2860
P356
P1476
Axonal degeneration is blocked ...... sduction into transected axons
@en
P2093
P2860
P304
41211-41215
P356
10.1074/JBC.C110.193904
P407
P577
2010-11-11T00:00:00Z