Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

http://www.wikidata.org/entity/Q30537596

about

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis.Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.Effect of 90Sr internal emitter on gene expression in mouse blood.The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1 Genomic rearrangements in sporadic lymphangioleiomyomatosis: an evolving genetic story.Modeling the Pro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia Predicts a Breakdown of Hematopoietic-Mesenchymal Communication Networks RasGRP Ras guanine nucleotide exchange factors in cancer.SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1.GFI1 as a novel prognostic and therapeutic factor for AML/MDS.Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature.Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.Enforced GFI1 expression impedes human and murine leukemic cell growth.GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis Gfi-1 promotes proliferation of human cervical carcinoma via targeting of FBW7 ubiquitin ligase expression

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P2860

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

http://www.wikidata.org/entity/Q30537596

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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type

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Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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Growth factor independence 1 a ...... way in lymphoblastic leukemia.

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J.CCR.2013.01.011

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Growth factor independence 1 a ...... hway in lymphoblastic leukemia

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James D Phelan

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Judith Schütte

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Lothar Vassen

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Riyan Chen

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Shane R Horman

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Tarik Möröy

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Ulrich Dührsen

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William E Paul

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P2860

p53 is regulated by the lysine demethylase LSD1

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Notch signaling controls multiple steps of pancreatic differentiation

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development

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2

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Berthold Gottgens

H. Leighton Grimes

Cyrus Khandanpour

Marie-Claude Gaudreau

Joseph Krongold

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2013-02-01T00:00:00Z

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235628231

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23410974

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